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Microbiota in Tumors: From Understanding to Application
Microbes with complex functions have been found to be a potential component in tumor microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is poorly understood. Mucosal sites and normal adjacent tissues are important sources of intratumor microbiota, while hematogeno...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313476/ https://www.ncbi.nlm.nih.gov/pubmed/35603968 http://dx.doi.org/10.1002/advs.202200470 |
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author | Xie, Yifan Xie, Feng Zhou, Xiaoxue Zhang, Lei Yang, Bing Huang, Jun Wang, Fangwei Yan, Haiyan Zeng, Linghui Zhang, Long Zhou, Fangfang |
author_facet | Xie, Yifan Xie, Feng Zhou, Xiaoxue Zhang, Lei Yang, Bing Huang, Jun Wang, Fangwei Yan, Haiyan Zeng, Linghui Zhang, Long Zhou, Fangfang |
author_sort | Xie, Yifan |
collection | PubMed |
description | Microbes with complex functions have been found to be a potential component in tumor microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is poorly understood. Mucosal sites and normal adjacent tissues are important sources of intratumor microbiota, while hematogenous spread also leads to the invasion of microbes. Intratumor microbiota affects the progression of tumors through several mechanisms, such as DNA damage, activation of oncogenic pathways, induction of immunosuppression, and metabolization of drugs. Notably, in different types of tumors, the composition and abundance of intratumor microbiota are highly heterogeneous and may play different roles in the progression of tumors. Because of the concern in this field, several techniques such as omics and immunological methods have been used to study intratumor microbiota. Here, recent progress in this field is reviewed, including the potential sources of intratumor microbiota, their functions and related mechanisms, and their heterogeneity. Techniques that can be used to study intratumor microbiota are also discussed. Moreover, research is summarized into the development of strategies that can be used in antitumor treatment and prospects for possible future research in this field. |
format | Online Article Text |
id | pubmed-9313476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93134762022-07-27 Microbiota in Tumors: From Understanding to Application Xie, Yifan Xie, Feng Zhou, Xiaoxue Zhang, Lei Yang, Bing Huang, Jun Wang, Fangwei Yan, Haiyan Zeng, Linghui Zhang, Long Zhou, Fangfang Adv Sci (Weinh) Reviews Microbes with complex functions have been found to be a potential component in tumor microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is poorly understood. Mucosal sites and normal adjacent tissues are important sources of intratumor microbiota, while hematogenous spread also leads to the invasion of microbes. Intratumor microbiota affects the progression of tumors through several mechanisms, such as DNA damage, activation of oncogenic pathways, induction of immunosuppression, and metabolization of drugs. Notably, in different types of tumors, the composition and abundance of intratumor microbiota are highly heterogeneous and may play different roles in the progression of tumors. Because of the concern in this field, several techniques such as omics and immunological methods have been used to study intratumor microbiota. Here, recent progress in this field is reviewed, including the potential sources of intratumor microbiota, their functions and related mechanisms, and their heterogeneity. Techniques that can be used to study intratumor microbiota are also discussed. Moreover, research is summarized into the development of strategies that can be used in antitumor treatment and prospects for possible future research in this field. John Wiley and Sons Inc. 2022-05-23 /pmc/articles/PMC9313476/ /pubmed/35603968 http://dx.doi.org/10.1002/advs.202200470 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Xie, Yifan Xie, Feng Zhou, Xiaoxue Zhang, Lei Yang, Bing Huang, Jun Wang, Fangwei Yan, Haiyan Zeng, Linghui Zhang, Long Zhou, Fangfang Microbiota in Tumors: From Understanding to Application |
title | Microbiota in Tumors: From Understanding to Application |
title_full | Microbiota in Tumors: From Understanding to Application |
title_fullStr | Microbiota in Tumors: From Understanding to Application |
title_full_unstemmed | Microbiota in Tumors: From Understanding to Application |
title_short | Microbiota in Tumors: From Understanding to Application |
title_sort | microbiota in tumors: from understanding to application |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313476/ https://www.ncbi.nlm.nih.gov/pubmed/35603968 http://dx.doi.org/10.1002/advs.202200470 |
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