Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer

Targeting the G2/M checkpoint mediator WEE1 has been explored as a novel treatment strategy in ovarian cancer, but mechanisms underlying its efficacy and resistance remains to be understood. Here, it is demonstrated that the WEE1 inhibitor AZD1775 induces endoplasmic reticulum stress and activates t...

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Detalles Bibliográficos
Autores principales: Xiao, Rourou, You, Lixin, Zhang, Li, Guo, Xichen, Guo, Ensong, Zhao, Faming, Yang, Bin, Li, Xi, Fu, Yu, Lu, Funian, Wang, Zizhuo, Liu, Chen, Peng, Wenju, Li, Wenting, Yang, Xiaohang, Dou, Yingyu, Liu, Jingbo, Wang, Wei, Qin, Tianyu, Cui, Yaoyuan, Zhang, Xiaoxiao, Li, Fuxia, Jin, Yang, Zeng, Qingping, Wang, Beibei, Mills, Gordon B., Chen, Gang, Sheng, Xia, Sun, Chaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313493/
https://www.ncbi.nlm.nih.gov/pubmed/35619328
http://dx.doi.org/10.1002/advs.202105469

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