Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop

Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, especially considering the different absorption sites of free bile...

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Detalles Bibliográficos
Autores principales: Deng, Feiyang, Kim, Kyoung Sub, Moon, Jiyoung, Bae, You Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313510/
https://www.ncbi.nlm.nih.gov/pubmed/35652273
http://dx.doi.org/10.1002/advs.202201414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313510/
https://www.ncbi.nlm.nih.gov/pubmed/35652273
http://dx.doi.org/10.1002/advs.202201414

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