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The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial
BACKGROUND: The popularity of the gluten‐free diet and sales of gluten‐free products have increased immensely. AIMS: To investigate whether gluten induces gastrointestinal symptoms, measured by self‐reported questionnaires, as well as mental health symptoms in adolescents from a population‐based coh...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313792/ https://www.ncbi.nlm.nih.gov/pubmed/35352373 http://dx.doi.org/10.1111/apt.16914 |
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author | Crawley, Caecilie Savino, Nadia Halby, Cecilie Sander, Stine Dydensborg Andersen, Anne‐Marie Nybo Arumugam, Manimozhiyan Murray, Joseph Christensen, Robin Husby, Steffen |
author_facet | Crawley, Caecilie Savino, Nadia Halby, Cecilie Sander, Stine Dydensborg Andersen, Anne‐Marie Nybo Arumugam, Manimozhiyan Murray, Joseph Christensen, Robin Husby, Steffen |
author_sort | Crawley, Caecilie |
collection | PubMed |
description | BACKGROUND: The popularity of the gluten‐free diet and sales of gluten‐free products have increased immensely. AIMS: To investigate whether gluten induces gastrointestinal symptoms, measured by self‐reported questionnaires, as well as mental health symptoms in adolescents from a population‐based cohort. METHODS: The eligible participants (n = 273) were recruited from a population‐based cohort of 1266 adolescents and had at least four different gastrointestinal symptoms. Phase one (n = 54) was a run‐in phase where the participants lived gluten‐free for 2 weeks. If they improved they continued to phase 2 (n = 33), a blinded randomised cross‐over trial. Participants were blindly randomised either to start with 7 days of gluten, eating two granola bars containing 10 g of gluten or to 7 days on placebo, eating two granola bars without gluten, followed by the reverse and separated by a 7‐day washout period. The effects of the intervention on gastrointestinal symptoms and mental health symptoms were assessed. RESULTS: In total, 54/273 participants entered the run‐in phase and 35 were eligible for randomization. A total of 33 were randomised and 32 completed the trial. The median age was 20.3 (IQR 19.2–20.9) and 32/33 participants were females. Compared with a placebo, gluten did not induce gastrointestinal symptoms. The difference in the average VAS was −0.01 (95% confidence interval −2.07 to 2.05). Nor did we find a difference in the outcomes measuring mental health. CONCLUSION: Compared with placebo, adding gluten to the diet did not induce gastrointestinal symptoms or worsened mental health in adolescents recruited from a population‐based cohort. The trial registration number is NCT04639921. |
format | Online Article Text |
id | pubmed-9313792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93137922022-07-30 The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial Crawley, Caecilie Savino, Nadia Halby, Cecilie Sander, Stine Dydensborg Andersen, Anne‐Marie Nybo Arumugam, Manimozhiyan Murray, Joseph Christensen, Robin Husby, Steffen Aliment Pharmacol Ther Clinical Trial BACKGROUND: The popularity of the gluten‐free diet and sales of gluten‐free products have increased immensely. AIMS: To investigate whether gluten induces gastrointestinal symptoms, measured by self‐reported questionnaires, as well as mental health symptoms in adolescents from a population‐based cohort. METHODS: The eligible participants (n = 273) were recruited from a population‐based cohort of 1266 adolescents and had at least four different gastrointestinal symptoms. Phase one (n = 54) was a run‐in phase where the participants lived gluten‐free for 2 weeks. If they improved they continued to phase 2 (n = 33), a blinded randomised cross‐over trial. Participants were blindly randomised either to start with 7 days of gluten, eating two granola bars containing 10 g of gluten or to 7 days on placebo, eating two granola bars without gluten, followed by the reverse and separated by a 7‐day washout period. The effects of the intervention on gastrointestinal symptoms and mental health symptoms were assessed. RESULTS: In total, 54/273 participants entered the run‐in phase and 35 were eligible for randomization. A total of 33 were randomised and 32 completed the trial. The median age was 20.3 (IQR 19.2–20.9) and 32/33 participants were females. Compared with a placebo, gluten did not induce gastrointestinal symptoms. The difference in the average VAS was −0.01 (95% confidence interval −2.07 to 2.05). Nor did we find a difference in the outcomes measuring mental health. CONCLUSION: Compared with placebo, adding gluten to the diet did not induce gastrointestinal symptoms or worsened mental health in adolescents recruited from a population‐based cohort. The trial registration number is NCT04639921. John Wiley and Sons Inc. 2022-03-29 2022-05 /pmc/articles/PMC9313792/ /pubmed/35352373 http://dx.doi.org/10.1111/apt.16914 Text en © 2022 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Clinical Trial Crawley, Caecilie Savino, Nadia Halby, Cecilie Sander, Stine Dydensborg Andersen, Anne‐Marie Nybo Arumugam, Manimozhiyan Murray, Joseph Christensen, Robin Husby, Steffen The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial |
title | The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial |
title_full | The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial |
title_fullStr | The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial |
title_full_unstemmed | The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial |
title_short | The effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial |
title_sort | effect of gluten in adolescents and young adults with gastrointestinal symptoms: a blinded randomised cross‐over trial |
topic | Clinical Trial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313792/ https://www.ncbi.nlm.nih.gov/pubmed/35352373 http://dx.doi.org/10.1111/apt.16914 |
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