Pandemic vaccine testing: Combining conventional and challenge studies

Early into COVID, human challenge trials were considered, but usually as alternatives to conventional randomized controlled trials. Instead, assessment of authorized COVID vaccines, of further COVID vaccines, and of vaccines against future pandemics should combine both designs, in five different way...

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Detalles Bibliográficos
Autores principales: Gerhard, Tobias, Strom, Brian L., Eyal, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313872/
https://www.ncbi.nlm.nih.gov/pubmed/35297119
http://dx.doi.org/10.1002/pds.5429
Descripción
Sumario:Early into COVID, human challenge trials were considered, but usually as alternatives to conventional randomized controlled trials. Instead, assessment of authorized COVID vaccines, of further COVID vaccines, and of vaccines against future pandemics should combine both designs, in five different ways, including a wholly novel one that we elaborate, Viz., combining data from both designs to answer a single question.

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