Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management

Germline CDH1 defects are related with the development of multiple cancers due its pleiotropic nature. These several conditions are associated with various risks of penetrance and with different clinical management strategies. In this clinical review, we described the penetrance risks of gastric, br...

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Detalles Bibliográficos
Autor principal: Corso, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
General Interest
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313879/
https://www.ncbi.nlm.nih.gov/pubmed/35277969
http://dx.doi.org/10.1002/jso.26847
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author Corso, Giovanni
author_facet Corso, Giovanni
author_sort Corso, Giovanni
collection PubMed
description Germline CDH1 defects are related with the development of multiple cancers due its pleiotropic nature. These several conditions are associated with various risks of penetrance and with different clinical management strategies. In this clinical review, we described the penetrance risks of gastric, breast, prostate, and colorectal cancers, in CDH1 carriers, within as well as outside the familial setting, and the best approaches to manage each risk, using either prophylactic surgery or surveillance.
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spelling pubmed-93138792022-07-30 Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management Corso, Giovanni J Surg Oncol General Interest Germline CDH1 defects are related with the development of multiple cancers due its pleiotropic nature. These several conditions are associated with various risks of penetrance and with different clinical management strategies. In this clinical review, we described the penetrance risks of gastric, breast, prostate, and colorectal cancers, in CDH1 carriers, within as well as outside the familial setting, and the best approaches to manage each risk, using either prophylactic surgery or surveillance. John Wiley and Sons Inc. 2022-03-12 2022-06-15 /pmc/articles/PMC9313879/ /pubmed/35277969 http://dx.doi.org/10.1002/jso.26847 Text en © 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle General Interest
Corso, Giovanni
Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management
title Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management
title_full Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management
title_fullStr Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management
title_full_unstemmed Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management
title_short Pleiotropic cancer manifestations of germline CDH1 mutations: Risks and management
title_sort pleiotropic cancer manifestations of germline cdh1 mutations: risks and management
topic General Interest
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313879/
https://www.ncbi.nlm.nih.gov/pubmed/35277969
http://dx.doi.org/10.1002/jso.26847
work_keys_str_mv AT corsogiovanni pleiotropiccancermanifestationsofgermlinecdh1mutationsrisksandmanagement

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