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Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms

Over the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardiovascular disease hypertension, stroke, and several malignanci...

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Autores principales: Saad, Bashar, Kmail, Abdalsalam, Haq, Sameena Z. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313926/
https://www.ncbi.nlm.nih.gov/pubmed/35899227
http://dx.doi.org/10.1155/2022/2276094
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author Saad, Bashar
Kmail, Abdalsalam
Haq, Sameena Z. H.
author_facet Saad, Bashar
Kmail, Abdalsalam
Haq, Sameena Z. H.
author_sort Saad, Bashar
collection PubMed
description Over the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardiovascular disease hypertension, stroke, and several malignancies. Therapeutic usage of medicinal plants and natural products in the treatment of diabetes and obesity has long been known to physicians of Greco-Arab and Islamic medicine. Improved versions of their abundant medicinal plant-based formulations are at present some of the most popular herbal treatments used. Preclinical and clinical data about medicinal plants along with their bioactive constituents are now available, justifying the traditionally known therapeutic uses of products derived from them for the prevention and cure of obesity-related T2D and other health problems. The aim of this review is to systematize published scientific data dealing with the efficiency of active ingredients or extracts from Middle Eastern medicinal plants and diet in the management of diabesity and its complications. Google Scholar, MEDLINE, and PubMed were searched for publications describing the medicinal plants and diet used in the management of T2D, obesity, and their complications. The used keywords were “medicinal plants” or “herbals” in combination with “obesity,” “diabetes,” “diabetes,” or nephropathy. More than 130 medicinal plants were identified to target diabesity and its complications. The antidiabetic and anti-obesity effects and action mechanisms of these plants are discussed here. These include the regulation of appetite, thermogenesis, lipid absorption, and lipolysis; pancreatic lipase activity and adipogenesis; glucose absorption in the intestine, insulin secretion, glucose transporters, gluconeogenesis, and epigenetic mechanisms.
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spelling pubmed-93139262022-07-26 Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms Saad, Bashar Kmail, Abdalsalam Haq, Sameena Z. H. Evid Based Complement Alternat Med Review Article Over the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardiovascular disease hypertension, stroke, and several malignancies. Therapeutic usage of medicinal plants and natural products in the treatment of diabetes and obesity has long been known to physicians of Greco-Arab and Islamic medicine. Improved versions of their abundant medicinal plant-based formulations are at present some of the most popular herbal treatments used. Preclinical and clinical data about medicinal plants along with their bioactive constituents are now available, justifying the traditionally known therapeutic uses of products derived from them for the prevention and cure of obesity-related T2D and other health problems. The aim of this review is to systematize published scientific data dealing with the efficiency of active ingredients or extracts from Middle Eastern medicinal plants and diet in the management of diabesity and its complications. Google Scholar, MEDLINE, and PubMed were searched for publications describing the medicinal plants and diet used in the management of T2D, obesity, and their complications. The used keywords were “medicinal plants” or “herbals” in combination with “obesity,” “diabetes,” “diabetes,” or nephropathy. More than 130 medicinal plants were identified to target diabesity and its complications. The antidiabetic and anti-obesity effects and action mechanisms of these plants are discussed here. These include the regulation of appetite, thermogenesis, lipid absorption, and lipolysis; pancreatic lipase activity and adipogenesis; glucose absorption in the intestine, insulin secretion, glucose transporters, gluconeogenesis, and epigenetic mechanisms. Hindawi 2022-07-18 /pmc/articles/PMC9313926/ /pubmed/35899227 http://dx.doi.org/10.1155/2022/2276094 Text en Copyright © 2022 Bashar Saad et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Saad, Bashar
Kmail, Abdalsalam
Haq, Sameena Z. H.
Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
title Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
title_full Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
title_fullStr Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
title_full_unstemmed Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
title_short Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
title_sort anti-diabesity middle eastern medicinal plants and their action mechanisms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313926/
https://www.ncbi.nlm.nih.gov/pubmed/35899227
http://dx.doi.org/10.1155/2022/2276094
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