Tricyclic antipsychotics and antidepressants can inhibit α5‐containing GABA(A) receptors by two distinct mechanisms

BACKGROUND AND PURPOSE: Many psychotherapeutic drugs, including clozapine, display polypharmacology and act on GABA(A) receptors. Patients with schizophrenia show alterations in function, structure and molecular composition of the hippocampus, and a recent study demonstrated aberrant levels of hippo...

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Detalles Bibliográficos
Autores principales: Bampali, Konstantina, Koniuszewski, Filip, Silva, Luca L., Rehman, Sabah, Vogel, Florian D., Seidel, Thomas, Scholze, Petra, Zirpel, Florian, Garon, Arthur, Langer, Thierry, Willeit, Matthäus, Ernst, Margot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314015/
https://www.ncbi.nlm.nih.gov/pubmed/35088415
http://dx.doi.org/10.1111/bph.15807

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