Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia

Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF‐associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by...

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Autores principales: Diebold, Martin, Galli, Edoardo, Kopf, Andreas, Sanderson, Nicholas, Callegari, Ilaria, Ingelfinger, Florian, Núñez, Nicolás Gonzalo, Benkert, Pascal, Kappos, Ludwig, Kuhle, Jens, Becher, Burkhard, Claassen, Manfred, Derfuss, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314128/
https://www.ncbi.nlm.nih.gov/pubmed/35170072
http://dx.doi.org/10.1002/ana.26328
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author Diebold, Martin
Galli, Edoardo
Kopf, Andreas
Sanderson, Nicholas
Callegari, Ilaria
Ingelfinger, Florian
Núñez, Nicolás Gonzalo
Benkert, Pascal
Kappos, Ludwig
Kuhle, Jens
Becher, Burkhard
Claassen, Manfred
Derfuss, Tobias
author_facet Diebold, Martin
Galli, Edoardo
Kopf, Andreas
Sanderson, Nicholas
Callegari, Ilaria
Ingelfinger, Florian
Núñez, Nicolás Gonzalo
Benkert, Pascal
Kappos, Ludwig
Kuhle, Jens
Becher, Burkhard
Claassen, Manfred
Derfuss, Tobias
author_sort Diebold, Martin
collection PubMed
description Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF‐associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single‐cell mass cytometry before and after 12 and 48 weeks of DMF therapy. Employing a neural network‐based representation learning approach, we identified a CCR4‐expressing T helper cell population negatively associated with relevant lymphopenia. CCR4‐expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment. ANN NEUROL 2022;91:676–681
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spelling pubmed-93141282022-07-30 Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia Diebold, Martin Galli, Edoardo Kopf, Andreas Sanderson, Nicholas Callegari, Ilaria Ingelfinger, Florian Núñez, Nicolás Gonzalo Benkert, Pascal Kappos, Ludwig Kuhle, Jens Becher, Burkhard Claassen, Manfred Derfuss, Tobias Ann Neurol Brief Communications Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF‐associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single‐cell mass cytometry before and after 12 and 48 weeks of DMF therapy. Employing a neural network‐based representation learning approach, we identified a CCR4‐expressing T helper cell population negatively associated with relevant lymphopenia. CCR4‐expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment. ANN NEUROL 2022;91:676–681 John Wiley & Sons, Inc. 2022-03-04 2022-05 /pmc/articles/PMC9314128/ /pubmed/35170072 http://dx.doi.org/10.1002/ana.26328 Text en © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Diebold, Martin
Galli, Edoardo
Kopf, Andreas
Sanderson, Nicholas
Callegari, Ilaria
Ingelfinger, Florian
Núñez, Nicolás Gonzalo
Benkert, Pascal
Kappos, Ludwig
Kuhle, Jens
Becher, Burkhard
Claassen, Manfred
Derfuss, Tobias
Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
title Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
title_full Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
title_fullStr Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
title_full_unstemmed Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
title_short Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
title_sort immunological predictors of dimethyl fumarate‐induced lymphopenia
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314128/
https://www.ncbi.nlm.nih.gov/pubmed/35170072
http://dx.doi.org/10.1002/ana.26328
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