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Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children

BACKGROUND: Some cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The microbiota of the first‐pass meconium, which forms before birth, represents the first gut microbiota that is easily available for research and little is known about an...

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Autores principales: Kielenniva, Katja, Ainonen, Sofia, Vänni, Petri, Paalanne, Niko, Renko, Marjo, Salo, Jarmo, Tejesvi, Mysore V., Pokka, Tytti, Pirttilä, Anna Maria, Tapiainen, Terhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314137/
https://www.ncbi.nlm.nih.gov/pubmed/35212058
http://dx.doi.org/10.1111/cea.14117
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author Kielenniva, Katja
Ainonen, Sofia
Vänni, Petri
Paalanne, Niko
Renko, Marjo
Salo, Jarmo
Tejesvi, Mysore V.
Pokka, Tytti
Pirttilä, Anna Maria
Tapiainen, Terhi
author_facet Kielenniva, Katja
Ainonen, Sofia
Vänni, Petri
Paalanne, Niko
Renko, Marjo
Salo, Jarmo
Tejesvi, Mysore V.
Pokka, Tytti
Pirttilä, Anna Maria
Tapiainen, Terhi
author_sort Kielenniva, Katja
collection PubMed
description BACKGROUND: Some cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The microbiota of the first‐pass meconium, which forms before birth, represents the first gut microbiota that is easily available for research and little is known about any relationship with allergic disease development. OBJECTIVE: We investigated whether the bacterial composition of the first‐pass meconium is associated with the development of allergic diseases before 4 years of age. METHODS: Prospective birth cohort study. Bacterial composition of first‐pass meconium was analysed using bacterial 16S rRNA gene amplicon sequencing. Atopic and allergic diseases were evaluated via online survey or telephone to age 4 years, based on the International Study of Asthma and Allergies in Childhood questionnaire. RESULTS: During a 6‐week period in 2014, 312 children were born at the Central Finland Central Hospital. Meconium was collected from 212 at a mean of 8‐hour age. Outcome data at 4 years were available for 177 (83%) children, and 159 of these had sufficient amplification of bacterial DNA in meconium. Meconium microbiota composition, including diversity indices and relative abundances of the main phyla and genera, was not associated with subsequent atopic eczema, wheezing or cow's milk allergy. Principal components analysis did not identify any clustering of the meconium microbiomes of children with respect to wheezing or cow's milk allergy. CONCLUSIONS: We found no evidence that gut microbiota composition of first‐pass meconium is associated with atopic manifestations to age 4 years. However, larger studies are needed to fully exclude a relationship.
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spelling pubmed-93141372022-07-30 Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children Kielenniva, Katja Ainonen, Sofia Vänni, Petri Paalanne, Niko Renko, Marjo Salo, Jarmo Tejesvi, Mysore V. Pokka, Tytti Pirttilä, Anna Maria Tapiainen, Terhi Clin Exp Allergy Original Articles BACKGROUND: Some cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The microbiota of the first‐pass meconium, which forms before birth, represents the first gut microbiota that is easily available for research and little is known about any relationship with allergic disease development. OBJECTIVE: We investigated whether the bacterial composition of the first‐pass meconium is associated with the development of allergic diseases before 4 years of age. METHODS: Prospective birth cohort study. Bacterial composition of first‐pass meconium was analysed using bacterial 16S rRNA gene amplicon sequencing. Atopic and allergic diseases were evaluated via online survey or telephone to age 4 years, based on the International Study of Asthma and Allergies in Childhood questionnaire. RESULTS: During a 6‐week period in 2014, 312 children were born at the Central Finland Central Hospital. Meconium was collected from 212 at a mean of 8‐hour age. Outcome data at 4 years were available for 177 (83%) children, and 159 of these had sufficient amplification of bacterial DNA in meconium. Meconium microbiota composition, including diversity indices and relative abundances of the main phyla and genera, was not associated with subsequent atopic eczema, wheezing or cow's milk allergy. Principal components analysis did not identify any clustering of the meconium microbiomes of children with respect to wheezing or cow's milk allergy. CONCLUSIONS: We found no evidence that gut microbiota composition of first‐pass meconium is associated with atopic manifestations to age 4 years. However, larger studies are needed to fully exclude a relationship. John Wiley and Sons Inc. 2022-03-03 2022-05 /pmc/articles/PMC9314137/ /pubmed/35212058 http://dx.doi.org/10.1111/cea.14117 Text en © 2022 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Kielenniva, Katja
Ainonen, Sofia
Vänni, Petri
Paalanne, Niko
Renko, Marjo
Salo, Jarmo
Tejesvi, Mysore V.
Pokka, Tytti
Pirttilä, Anna Maria
Tapiainen, Terhi
Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children
title Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children
title_full Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children
title_fullStr Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children
title_full_unstemmed Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children
title_short Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children
title_sort microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314137/
https://www.ncbi.nlm.nih.gov/pubmed/35212058
http://dx.doi.org/10.1111/cea.14117
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