TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but also depends on mitochondrial pathways. Yet, how these two organelle systems communicate is largely unknown. Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator for pha...

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Detalles Bibliográficos
Autores principales: Schuster, Ev-Marie, Epple, Maximilian W., Glaser, Katharina M., Mihlan, Michael, Lucht, Kerstin, Zimmermann, Julia A., Bremser, Anna, Polyzou, Aikaterini, Obier, Nadine, Cabezas-Wallscheid, Nina, Trompouki, Eirini, Ballabio, Andrea, Vogel, Jörg, Buescher, Joerg M., Westermann, Alexander J., Rambold, Angelika S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314259/
https://www.ncbi.nlm.nih.gov/pubmed/35864246
http://dx.doi.org/10.1038/s42255-022-00605-w

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