A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient

A lung transplant (LT) patient developed 2 distinct episodes of COVID-19, confirmed by whole-genome sequencing, which was caused by the Delta, and then followed 6 weeks later, by the Omicron variant. The clinical course with Omicron was more severe, leading us to speculate that Omicron may not be an...

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Autores principales: Mahan, Luke D., Mohanka, Manish R., Joerns, John, Lawrence, Adrian, Bollineni, Srinivas, Kaza, Vaidehi, Timofte, Irina, La Hoz, Ricardo M., Sorelle, Jeffrey, Terada, Lance S., Kershaw, Corey D., Torres, Fernando, Banga, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314265/
https://www.ncbi.nlm.nih.gov/pubmed/36116948
http://dx.doi.org/10.1016/j.transproceed.2022.07.003
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author Mahan, Luke D.
Mohanka, Manish R.
Joerns, John
Lawrence, Adrian
Bollineni, Srinivas
Kaza, Vaidehi
Timofte, Irina
La Hoz, Ricardo M.
Sorelle, Jeffrey
Terada, Lance S.
Kershaw, Corey D.
Torres, Fernando
Banga, Amit
author_facet Mahan, Luke D.
Mohanka, Manish R.
Joerns, John
Lawrence, Adrian
Bollineni, Srinivas
Kaza, Vaidehi
Timofte, Irina
La Hoz, Ricardo M.
Sorelle, Jeffrey
Terada, Lance S.
Kershaw, Corey D.
Torres, Fernando
Banga, Amit
author_sort Mahan, Luke D.
collection PubMed
description A lung transplant (LT) patient developed 2 distinct episodes of COVID-19, confirmed by whole-genome sequencing, which was caused by the Delta, and then followed 6 weeks later, by the Omicron variant. The clinical course with Omicron was more severe, leading us to speculate that Omicron may not be any milder among LT patients. We discuss the potential mechanisms behind the Omicron not being any milder among LT patients and emphasize the need for outcomes data among these patients. Until such data become available, it may be prudent to maintain clinical equipoise as regards the relative virulence of the newer variants among LT patients.
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spelling pubmed-93142652022-07-26 A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient Mahan, Luke D. Mohanka, Manish R. Joerns, John Lawrence, Adrian Bollineni, Srinivas Kaza, Vaidehi Timofte, Irina La Hoz, Ricardo M. Sorelle, Jeffrey Terada, Lance S. Kershaw, Corey D. Torres, Fernando Banga, Amit Transplant Proc Article A lung transplant (LT) patient developed 2 distinct episodes of COVID-19, confirmed by whole-genome sequencing, which was caused by the Delta, and then followed 6 weeks later, by the Omicron variant. The clinical course with Omicron was more severe, leading us to speculate that Omicron may not be any milder among LT patients. We discuss the potential mechanisms behind the Omicron not being any milder among LT patients and emphasize the need for outcomes data among these patients. Until such data become available, it may be prudent to maintain clinical equipoise as regards the relative virulence of the newer variants among LT patients. Elsevier Inc. 2022-12 2022-07-26 /pmc/articles/PMC9314265/ /pubmed/36116948 http://dx.doi.org/10.1016/j.transproceed.2022.07.003 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mahan, Luke D.
Mohanka, Manish R.
Joerns, John
Lawrence, Adrian
Bollineni, Srinivas
Kaza, Vaidehi
Timofte, Irina
La Hoz, Ricardo M.
Sorelle, Jeffrey
Terada, Lance S.
Kershaw, Corey D.
Torres, Fernando
Banga, Amit
A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient
title A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient
title_full A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient
title_fullStr A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient
title_full_unstemmed A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient
title_short A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient
title_sort case report of breakthrough infections with 2 sars-cov-2 variants in a lung transplant patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314265/
https://www.ncbi.nlm.nih.gov/pubmed/36116948
http://dx.doi.org/10.1016/j.transproceed.2022.07.003
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