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Structural basis of human TREX1 DNA degradation and autoimmune disease

TREX1 is a cytosolic DNA nuclease essential for regulation of cGAS-STING immune signaling. Existing structures of mouse TREX1 establish a mechanism of DNA degradation and provide a key model to explain autoimmune disease, but these structures incompletely explain human disease-associated mutations a...

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Detalles Bibliográficos
Autores principales:	Zhou, Wen, Richmond-Buccola, Desmond, Wang, Qiannan, Kranzusch, Philip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314330/ https://www.ncbi.nlm.nih.gov/pubmed/35879334 http://dx.doi.org/10.1038/s41467-022-32055-z

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