Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement

Cancer associated fibroblasts (CAFs) support tumors via multiple mechanisms, including maintaining the immunosuppressive tumor microenvironment and limiting infiltration of immune cells. The prolyl isomerase Pin1, whose overexpression in CAFs has not been fully profiled yet, plays critical roles in...

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Detalles Bibliográficos
Autores principales: Liu, Jiaye, Wang, Yang, Mu, Chunyang, Li, Meng, Li, Kewei, Li, Shan, Wu, Wenshuang, Du, Lingyao, Zhang, Xiaoyun, Li, Chuan, Peng, Wei, Shen, Junyi, Liu, Yang, Yang, Dujiang, Zhang, Kaixiang, Ning, Qingyang, Fu, Xiaoying, Zeng, Yu, Ni, Yinyun, Zhou, Zongguang, Liu, Yi, Hu, Yiguo, Zheng, Xiaofeng, Wen, Tianfu, Li, Zhihui, Liu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314377/
https://www.ncbi.nlm.nih.gov/pubmed/35879297
http://dx.doi.org/10.1038/s41467-022-31928-7

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