A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection

A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated vaccine vector (Modified Vaccinia Ankara, MVA) with the authentic conformation of virus-like particles (VLPs). The vaccine expresses minimal component...

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Autores principales: Malherbe, Delphine C., Domi, Arban, Hauser, Mary J., Atyeo, Caroline, Fischinger, Stephanie, Hyde, Matthew A., Williams, Julie M., Alter, Galit, Guirakhoo, Farshad, Bukreyev, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314403/
https://www.ncbi.nlm.nih.gov/pubmed/35879311
http://dx.doi.org/10.1038/s41541-022-00512-x
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author Malherbe, Delphine C.
Domi, Arban
Hauser, Mary J.
Atyeo, Caroline
Fischinger, Stephanie
Hyde, Matthew A.
Williams, Julie M.
Alter, Galit
Guirakhoo, Farshad
Bukreyev, Alexander
author_facet Malherbe, Delphine C.
Domi, Arban
Hauser, Mary J.
Atyeo, Caroline
Fischinger, Stephanie
Hyde, Matthew A.
Williams, Julie M.
Alter, Galit
Guirakhoo, Farshad
Bukreyev, Alexander
author_sort Malherbe, Delphine C.
collection PubMed
description A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated vaccine vector (Modified Vaccinia Ankara, MVA) with the authentic conformation of virus-like particles (VLPs). The vaccine expresses minimal components to generate self-assembling VLPs in the vaccinee: the envelope glycoprotein GP and the matrix protein VP40. Guinea pigs vaccinated with one dose of MVA-VLP-SUDV generated SUDV-specific binding and neutralizing antibody responses as well as Fc-mediated protective effects. These responses were boosted by a second vaccine dose. All vaccinated animals which received either one or two vaccine doses were protected from death and disease symptoms following challenge with a lethal dose of SUDV. These data demonstrate single dose protection and potency of the MVA-VLP platform for use in emergency situations to contain outbreaks.
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spelling pubmed-93144032022-07-27 A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection Malherbe, Delphine C. Domi, Arban Hauser, Mary J. Atyeo, Caroline Fischinger, Stephanie Hyde, Matthew A. Williams, Julie M. Alter, Galit Guirakhoo, Farshad Bukreyev, Alexander NPJ Vaccines Article A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated vaccine vector (Modified Vaccinia Ankara, MVA) with the authentic conformation of virus-like particles (VLPs). The vaccine expresses minimal components to generate self-assembling VLPs in the vaccinee: the envelope glycoprotein GP and the matrix protein VP40. Guinea pigs vaccinated with one dose of MVA-VLP-SUDV generated SUDV-specific binding and neutralizing antibody responses as well as Fc-mediated protective effects. These responses were boosted by a second vaccine dose. All vaccinated animals which received either one or two vaccine doses were protected from death and disease symptoms following challenge with a lethal dose of SUDV. These data demonstrate single dose protection and potency of the MVA-VLP platform for use in emergency situations to contain outbreaks. Nature Publishing Group UK 2022-07-25 /pmc/articles/PMC9314403/ /pubmed/35879311 http://dx.doi.org/10.1038/s41541-022-00512-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Malherbe, Delphine C.
Domi, Arban
Hauser, Mary J.
Atyeo, Caroline
Fischinger, Stephanie
Hyde, Matthew A.
Williams, Julie M.
Alter, Galit
Guirakhoo, Farshad
Bukreyev, Alexander
A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
title A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
title_full A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
title_fullStr A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
title_full_unstemmed A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
title_short A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
title_sort single immunization with a modified vaccinia ankara vectored vaccine producing sudan virus-like particles protects from lethal infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314403/
https://www.ncbi.nlm.nih.gov/pubmed/35879311
http://dx.doi.org/10.1038/s41541-022-00512-x
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