Activation of the JNKs/ATM-p53 axis is indispensable for the cytoprotection of dermal fibroblasts exposed to UVB radiation

Although UVB radiation is mainly absorbed by the epidermis, ~5–10% of its photons reach and affect the upper part of the dermis. Physiologically relevant UVB doses, able to provoke erythema, induce apoptosis in human dermal fibroblasts in vitro, as well as in the dermis of SKH-1 mice. Given the spar...

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Detalles Bibliográficos
Autores principales: Mavrogonatou, Eleni, Angelopoulou, Maria, Rizou, Sophia V., Pratsinis, Harris, Gorgoulis, Vassilis G., Kletsas, Dimitris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314411/
https://www.ncbi.nlm.nih.gov/pubmed/35879280
http://dx.doi.org/10.1038/s41419-022-05106-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314411/
https://www.ncbi.nlm.nih.gov/pubmed/35879280
http://dx.doi.org/10.1038/s41419-022-05106-y

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