Cargando…

Pharmacokinetics of Buprenorphine Buccal Film and Orally-administered Oxycodone in a Respiratory Study: An Analysis of Secondary Outcomes from a Randomized Controlled Trial

OBJECTIVE: To evaluate pharmacokinetic (PK) parameters and oxygen saturation as markers of abuse potential after administration of buprenorphine buccal film (BBF) and immediate-release (IR) oxycodone. METHODS: This was a secondary analysis of data from a phase I randomized controlled trial. A total...

Descripción completa

Detalles Bibliográficos
Autores principales:	Webster, Lynn R., Cater, Jacqueline, Smith, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Healthcare 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314471/ https://www.ncbi.nlm.nih.gov/pubmed/35524938 http://dx.doi.org/10.1007/s40122-022-00380-2

Ejemplares similares

A Phase I Placebo-Controlled Trial Comparing the Effects of Buprenorphine Buccal Film and Oral Oxycodone Hydrochloride Administration on Respiratory Drive
por: Webster, Lynn R., et al.
Publicado: (2020)

Relative Oral Bioavailability of an Abuse-Deterrent, Immediate-Release Formulation of Oxycodone, Oxycodone ARIR in a Randomized Study
por: Webster, Lynn R., et al.
Publicado: (2019)

Methadone, Buprenorphine, Oxycodone, Fentanyl and Tramadol in Multiple Postmortem Matrices
por: Havig, Stine Marie, et al.
Publicado: (2021)

Evaluation of the Tolerability of Switching Patients on Chronic Full μ-Opioid Agonist Therapy to Buccal Buprenorphine
por: Webster, Lynn, et al.
Publicado: (2016)

Single-Dose Pharmacokinetics of Fentanyl Buccal Soluble Film
por: Vasisht, Niraj, et al.
Publicado: (2010)

Pharmacokinetics of orally administered single‐dose ponazuril in cats
por: Burlison, Catherine, et al.
Publicado: (2022)

Effects of Aprepitant on the Pharmacokinetics of Controlled-Release Oral Oxycodone in Cancer Patients
por: Fujiwara, Yutaka, et al.
Publicado: (2014)

Effects of intravenous oxycodone alone or in combination with naltrexone on measures of respiratory depression: a randomized placebo-controlled study
por: Bass, Almasa, et al.
Publicado: (2019)

Pharmacokinetics of Orally Administered Prednisolone in Alpacas
por: Videla, Ricardo, et al.
Publicado: (2021)

A Randomized, Double-Blind, Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone
por: Webster, Lynn R., et al.
Publicado: (2016)

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats
por: Doodnaught, Graeme M., et al.
Publicado: (2017)

A comparison of oral controlled-release morphine and oxycodone with transdermal formulations of buprenorphine and fentanyl in the treatment of severe pain in cancer patients
por: Nosek, Krzysztof, et al.
Publicado: (2017)

Respiratory effects of oral mitragynine and oxycodone in a rodent model
por: Henningfield, Jack E., et al.
Publicado: (2022)

Management of moderate to severe chronic low back pain with buprenorphine buccal film using novel bioerodible mucoadhesive technology
por: Pergolizzi, Joseph V, et al.
Publicado: (2016)

Abuse Potential Study of ALO-02 (Extended-Release Oxycodone Surrounding Sequestered Naltrexone) Compared with Immediate-Release Oxycodone Administered Orally to Nondependent Recreational Opioid Users
por: Setnik, Beatrice, et al.
Publicado: (2017)

Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users
por: Harris, Stephen C, et al.
Publicado: (2014)

Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs
por: Enomoto, Hiroko, et al.
Publicado: (2022)

Randomized, double-blind, placebo-controlled and active-controlled study to assess the relative abuse potential of oxycodone HCl-niacin tablets compared with oxycodone alone in nondependent, recreational opioid users
por: Webster, Lynn R, et al.
Publicado: (2012)

Pharmacokinetics of transdermal buprenorphine patch in the elderly
por: Al-Tawil, Nabil, et al.
Publicado: (2012)

Transition from Oxycodone to Buprenorphine/Naloxone in a Hospitalized Patient with Sickle Cell Disease: A Case Report
por: Leyde, Sarah, et al.
Publicado: (2022)

Long-term safety and analgesic efficacy of buprenorphine buccal film in patients with moderate-to-severe chronic pain requiring around-the-clock opioids
por: Hale, Martin, et al.
Publicado: (2017)

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs
por: Shugarts, Sarah, et al.
Publicado: (2009)

Pharmacokinetics of Orally Administered GS-441524 in Dogs
por: Yan, Victoria C., et al.
Publicado: (2021)

Pooled post hoc analysis of population pharmacokinetics of oxycodone and acetaminophen following a single oral dose of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets
por: Franke, Ryan M, et al.
Publicado: (2015)

Pharmacokinetics of morphine and oxycodone following intravenous administration in elderly patients
por: Villesen, Hanne H, et al.
Publicado: (2007)

Population Pharmacokinetics of Oxycodone and Metabolites in Patients with Cancer-Related Pain
por: Agema, Bram C., et al.
Publicado: (2021)

Oxycodone-Related Deaths: The Significance of Pharmacokinetic and Pharmacodynamic Drug Interactions
por: Jakobsson, Gerd, et al.
Publicado: (2022)

Low-dose naloxone provides an abuse-deterrent effect to buprenorphine
por: Webster, Lynn R, et al.
Publicado: (2015)

Pharmacokinetics of orally administered melatonin in critically ill patients
por: Moroni, B, et al.
Publicado: (2010)

Effects of renal impairment on the pharmacokinetics of orally administered deferiprone
por: Fradette, Caroline, et al.
Publicado: (2016)

Pharmacokinetic Aspects of Nanoparticle-in-Matrix Drug Delivery Systems for Oral/Buccal Delivery
por: Feitosa, Renata Carvalho, et al.
Publicado: (2019)

Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study
por: Safhi, Awaji Y., et al.
Publicado: (2023)

Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis
por: Lazzari, Marzia, et al.
Publicado: (2015)

Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection
por: Hakomäki, Henriikka, et al.
Publicado: (2021)

Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration
por: Olsson Gisleskog, Per O., et al.
Publicado: (2020)

Pharmacokinetic and pharmacodynamic properties of orally administered torsemide in healthy horses
por: Agne, Gustavo F., et al.
Publicado: (2018)

Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats
por: Roche‐Catholy, Marine, et al.
Publicado: (2022)

Physiologically‐based pharmacokinetic model of vaginally administered dapivirine ring and film formulations
por: Kay, Katherine, et al.
Publicado: (2018)

Formulation and Evaluation of Nitrendipine Buccal Films
por: Nappinnai, M., et al.
Publicado: (2008)

Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats
por: Pravetoni, Marco, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_o0i46bnamucc2eh26kop9k9p89