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Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study

INTRODUCTION: Opioid use disorder is a global problem. Although opioid analgesics are prescribed less frequently in Japan than in many other countries, the rate of aberrant prescription opioid-taking behaviors in Japan is unknown. METHODS: An internet survey was conducted to estimate the prevalence...

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Autores principales: Takasusuki, Toshifumi, Hayashi, Shinji, Koretaka, Yuichi, Yamaguchi, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314531/
https://www.ncbi.nlm.nih.gov/pubmed/35790601
http://dx.doi.org/10.1007/s40122-022-00409-6
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author Takasusuki, Toshifumi
Hayashi, Shinji
Koretaka, Yuichi
Yamaguchi, Shigeki
author_facet Takasusuki, Toshifumi
Hayashi, Shinji
Koretaka, Yuichi
Yamaguchi, Shigeki
author_sort Takasusuki, Toshifumi
collection PubMed
description INTRODUCTION: Opioid use disorder is a global problem. Although opioid analgesics are prescribed less frequently in Japan than in many other countries, the rate of aberrant prescription opioid-taking behaviors in Japan is unknown. METHODS: An internet survey was conducted to estimate the prevalence of and risk factors for prescription opioid misuse, abuse, diversion and doctor shopping in Japanese subjects with chronic pain who had been prescribed opioid analgesics. RESULTS: The proportion of respondents (n = 387) who reported opioid misuse was 45.5% (95% confidence interval [CI]: 40.4–50.6); rates were: 24.6% (95% CI: 20.3–29.2) for abuse; 15.0% (95% CI: 11.6–19.0) for diversion; and 10.6% (95% CI: 7.7–14.1) for doctor shopping. Aberrant prescription opioid-taking behaviors were higher in participants with chronic post-cancer treatment pain (misuse, 64.2%; abuse, 52.2%) or chronic cancer pain (misuse, 57.4%; abuse, 26.2%) than in those with chronic noncancer pain (misuse, 37.8%; abuse, 17.0%). Younger age, male sex, smoking, habitual drinking, diagnosis of psychiatric disease, use of opioids other than tramadol, and use of opioids for chronic post-cancer treatment pain and chronic cancer pain were identified as risk factors for aberrant prescription opioid-taking behaviors. CONCLUSION: Even in Japan, which has not experienced the surge in opioid consumption documented in other countries, aberrant prescription opioid-taking behaviors were observed. When prescribing opioid analgesics, universal precautions should always be taken for both cancer and non-cancer patients. TRIAL REGISTRATION: UMIN000041788. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40122-022-00409-6.
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spelling pubmed-93145312022-07-27 Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study Takasusuki, Toshifumi Hayashi, Shinji Koretaka, Yuichi Yamaguchi, Shigeki Pain Ther Original Research INTRODUCTION: Opioid use disorder is a global problem. Although opioid analgesics are prescribed less frequently in Japan than in many other countries, the rate of aberrant prescription opioid-taking behaviors in Japan is unknown. METHODS: An internet survey was conducted to estimate the prevalence of and risk factors for prescription opioid misuse, abuse, diversion and doctor shopping in Japanese subjects with chronic pain who had been prescribed opioid analgesics. RESULTS: The proportion of respondents (n = 387) who reported opioid misuse was 45.5% (95% confidence interval [CI]: 40.4–50.6); rates were: 24.6% (95% CI: 20.3–29.2) for abuse; 15.0% (95% CI: 11.6–19.0) for diversion; and 10.6% (95% CI: 7.7–14.1) for doctor shopping. Aberrant prescription opioid-taking behaviors were higher in participants with chronic post-cancer treatment pain (misuse, 64.2%; abuse, 52.2%) or chronic cancer pain (misuse, 57.4%; abuse, 26.2%) than in those with chronic noncancer pain (misuse, 37.8%; abuse, 17.0%). Younger age, male sex, smoking, habitual drinking, diagnosis of psychiatric disease, use of opioids other than tramadol, and use of opioids for chronic post-cancer treatment pain and chronic cancer pain were identified as risk factors for aberrant prescription opioid-taking behaviors. CONCLUSION: Even in Japan, which has not experienced the surge in opioid consumption documented in other countries, aberrant prescription opioid-taking behaviors were observed. When prescribing opioid analgesics, universal precautions should always be taken for both cancer and non-cancer patients. TRIAL REGISTRATION: UMIN000041788. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40122-022-00409-6. Springer Healthcare 2022-07-05 2022-09 /pmc/articles/PMC9314531/ /pubmed/35790601 http://dx.doi.org/10.1007/s40122-022-00409-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Takasusuki, Toshifumi
Hayashi, Shinji
Koretaka, Yuichi
Yamaguchi, Shigeki
Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study
title Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study
title_full Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study
title_fullStr Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study
title_full_unstemmed Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study
title_short Prevalence of and Risk Factors for Prescription Opioid Misuse, Abuse, Diversion and Doctor Shopping in Japan: A Survey Study
title_sort prevalence of and risk factors for prescription opioid misuse, abuse, diversion and doctor shopping in japan: a survey study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314531/
https://www.ncbi.nlm.nih.gov/pubmed/35790601
http://dx.doi.org/10.1007/s40122-022-00409-6
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