Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy

Leber’s hereditary optic neuropathy (LHON), a disease associated with a mitochondrial DNA mutation, is characterized by blindness due to degeneration of retinal ganglion cells (RGCs) and their axons, which form the optic nerve. We show that a sustained pathological autophagy and compartment-specific...

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Detalles Bibliográficos
Autores principales: Danese, Alberto, Patergnani, Simone, Maresca, Alessandra, Peron, Camille, Raimondi, Andrea, Caporali, Leonardo, Marchi, Saverio, La Morgia, Chiara, Del Dotto, Valentina, Zanna, Claudia, Iannielli, Angelo, Segnali, Alice, Di Meo, Ivano, Cavaliere, Andrea, Lebiedzinska-Arciszewska, Magdalena, Wieckowski, Mariusz R., Martinuzzi, Andrea, Moraes-Filho, Milton N., Salomao, Solange R., Berezovsky, Adriana, Belfort, Rubens, Buser, Christopher, Ross-Cisneros, Fred N., Sadun, Alfredo A., Tacchetti, Carlo, Broccoli, Vania, Giorgi, Carlotta, Tiranti, Valeria, Carelli, Valerio, Pinton, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314546/
https://www.ncbi.nlm.nih.gov/pubmed/35858578
http://dx.doi.org/10.1016/j.celrep.2022.111124

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