Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice

BACKGROUND AND PURPOSE: The kynurenine pathway has been proposed as a target for modulating drug abuse. We previously demonstrated that inhibition of kynurenine 3‐monooxygenase (KMO), using Ro 61‐8048, reduces ethanol consumption in a binge drinking model. Here, we investigate the effect of the kynu...

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Detalles Bibliográficos
Autores principales: Gil de Biedma‐Elduayen, Leticia, Giménez‐Gómez, Pablo, Morales‐Puerto, Nuria, Vidal, Rebeca, Núñez‐de la Calle, Carlos, Gutiérrez‐López, María Dolores, O'Shea, Esther, Colado, María Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314579/
https://www.ncbi.nlm.nih.gov/pubmed/35189673
http://dx.doi.org/10.1111/bph.15825

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