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Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial
OBJECTIVES: To assess the adjunctive effect of systemic amoxicillin (AMX) and metronidazole (MTZ) in patients receiving non‐surgical treatment (NST) for peri‐implantitis (PI). MATERIALS AND METHODS: Thirty‐seven patients were randomized into an experimental group treated with NST plus AMX + MTZ (N =...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314590/ https://www.ncbi.nlm.nih.gov/pubmed/35238084 http://dx.doi.org/10.1111/clr.13914 |
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author | Polymeri, Angeliki van der Horst, Joyce Anssari Moin, David Wismeijer, Daniel Loos, Bruno G. Laine, Marja L. |
author_facet | Polymeri, Angeliki van der Horst, Joyce Anssari Moin, David Wismeijer, Daniel Loos, Bruno G. Laine, Marja L. |
author_sort | Polymeri, Angeliki |
collection | PubMed |
description | OBJECTIVES: To assess the adjunctive effect of systemic amoxicillin (AMX) and metronidazole (MTZ) in patients receiving non‐surgical treatment (NST) for peri‐implantitis (PI). MATERIALS AND METHODS: Thirty‐seven patients were randomized into an experimental group treated with NST plus AMX + MTZ (N = 18) and a control group treated with NST alone (N = 19). Clinical parameters were evaluated at 12 weeks post‐treatment. The primary outcome was the change in peri‐implant pocket depth (PIPD) from baseline to 12 weeks, while secondary outcomes included bleeding on probing (BoP), suppuration on probing (SoP), and plaque. Data analysis was performed at patient level (one target site per patient). RESULTS: All 37 patients completed the study. Both groups showed a significant PIPD reduction after NST. The antibiotics group showed a higher mean reduction in PIPD at 12 weeks, compared with the control group (2.28 ± 1.49 mm vs. 1.47 ± 1.95 mm), however, this difference did not reach statistical significance. There was no significant effect of various potential confounders on PIPD reduction. Neither treatment resulted in significant improvements in BoP at follow‐up; 30 of 37 (81%) target sites still had BoP after treatment. Only two implants, one in each group, exhibited a successful outcome defined as PIPD < 5 mm, and absence of BoP and SoP. CONCLUSIONS: Non‐surgical treatment was able to reduce PIPD at implants with PI. The adjunctive use of systemic AMX and MTZ did not show statistically significant better results compared to NST alone. NST with or without antibiotics was ineffective to completely resolve inflammation around dental implants. |
format | Online Article Text |
id | pubmed-9314590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93145902022-07-30 Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial Polymeri, Angeliki van der Horst, Joyce Anssari Moin, David Wismeijer, Daniel Loos, Bruno G. Laine, Marja L. Clin Oral Implants Res Original Articles OBJECTIVES: To assess the adjunctive effect of systemic amoxicillin (AMX) and metronidazole (MTZ) in patients receiving non‐surgical treatment (NST) for peri‐implantitis (PI). MATERIALS AND METHODS: Thirty‐seven patients were randomized into an experimental group treated with NST plus AMX + MTZ (N = 18) and a control group treated with NST alone (N = 19). Clinical parameters were evaluated at 12 weeks post‐treatment. The primary outcome was the change in peri‐implant pocket depth (PIPD) from baseline to 12 weeks, while secondary outcomes included bleeding on probing (BoP), suppuration on probing (SoP), and plaque. Data analysis was performed at patient level (one target site per patient). RESULTS: All 37 patients completed the study. Both groups showed a significant PIPD reduction after NST. The antibiotics group showed a higher mean reduction in PIPD at 12 weeks, compared with the control group (2.28 ± 1.49 mm vs. 1.47 ± 1.95 mm), however, this difference did not reach statistical significance. There was no significant effect of various potential confounders on PIPD reduction. Neither treatment resulted in significant improvements in BoP at follow‐up; 30 of 37 (81%) target sites still had BoP after treatment. Only two implants, one in each group, exhibited a successful outcome defined as PIPD < 5 mm, and absence of BoP and SoP. CONCLUSIONS: Non‐surgical treatment was able to reduce PIPD at implants with PI. The adjunctive use of systemic AMX and MTZ did not show statistically significant better results compared to NST alone. NST with or without antibiotics was ineffective to completely resolve inflammation around dental implants. John Wiley and Sons Inc. 2022-03-15 2022-05 /pmc/articles/PMC9314590/ /pubmed/35238084 http://dx.doi.org/10.1111/clr.13914 Text en © 2022 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Polymeri, Angeliki van der Horst, Joyce Anssari Moin, David Wismeijer, Daniel Loos, Bruno G. Laine, Marja L. Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial |
title | Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial |
title_full | Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial |
title_fullStr | Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial |
title_full_unstemmed | Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial |
title_short | Non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial |
title_sort | non‐surgical peri‐implantitis treatment with or without systemic antibiotics: a randomized controlled clinical trial |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314590/ https://www.ncbi.nlm.nih.gov/pubmed/35238084 http://dx.doi.org/10.1111/clr.13914 |
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