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Cyclobutanes in Small‐Molecule Drug Candidates

Cyclobutanes are increasingly used in medicinal chemistry in the search for relevant biological properties. Important characteristics of the cyclobutane ring include its unique puckered structure, longer C−C bond lengths, increased C−C π‐character and relative chemical inertness for a highly straine...

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Detalles Bibliográficos
Autores principales:	van der Kolk, Marnix R., Janssen, Mathilde A. C. H., Rutjes, Floris P. J. T., Blanco‐Ania, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314592/ https://www.ncbi.nlm.nih.gov/pubmed/35263505 http://dx.doi.org/10.1002/cmdc.202200020

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