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Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes

OBJECTIVE: This study sought to assess whether diabetes affects coronary microvascular function in individuals with normal body weight. METHODS: Seventy‐five participants (30 patients with type 2 diabetes [T2D] who were overweight [O‐T2D], 15 patients with T2D who were lean [LnT2D], 15 healthy volun...

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Autores principales: Chowdhary, Amrit, Thirunavukarasu, Sharmaine, Jex, Nicholas, Coles, Lauren, Bowers, Charles, Sengupta, Anshuman, Swoboda, Peter, Witte, Klaus, Cubbon, Richard, Xue, Hui, Kellman, Peter, Greenwood, John, Plein, Sven, Levelt, Eylem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314597/
https://www.ncbi.nlm.nih.gov/pubmed/35357083
http://dx.doi.org/10.1002/oby.23413
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author Chowdhary, Amrit
Thirunavukarasu, Sharmaine
Jex, Nicholas
Coles, Lauren
Bowers, Charles
Sengupta, Anshuman
Swoboda, Peter
Witte, Klaus
Cubbon, Richard
Xue, Hui
Kellman, Peter
Greenwood, John
Plein, Sven
Levelt, Eylem
author_facet Chowdhary, Amrit
Thirunavukarasu, Sharmaine
Jex, Nicholas
Coles, Lauren
Bowers, Charles
Sengupta, Anshuman
Swoboda, Peter
Witte, Klaus
Cubbon, Richard
Xue, Hui
Kellman, Peter
Greenwood, John
Plein, Sven
Levelt, Eylem
author_sort Chowdhary, Amrit
collection PubMed
description OBJECTIVE: This study sought to assess whether diabetes affects coronary microvascular function in individuals with normal body weight. METHODS: Seventy‐five participants (30 patients with type 2 diabetes [T2D] who were overweight [O‐T2D], 15 patients with T2D who were lean [LnT2D], 15 healthy volunteers who were lean [LnHV], and 15 healthy volunteers who were overweight [O‐HV]) without established cardiovascular disease were recruited. Participants underwent magnetic resonance imaging for assessment of subcutaneous, epicardial, and visceral adipose tissue areas, adenosine stress myocardial blood flow (MBF), and cardiac structure and function. RESULTS: Stress MBF was reduced only in the O‐T2D group (mean [SD], LnHV = 2.07 [0.47] mL/g/min, O‐HV = 2.08 [0.42] mL/g/min, LnT2D = 2.16 [0.36] mL/g/min, O‐T2D = 1.60 [0.28] mL/g/min; p ≤ 0.0001). Accumulation of visceral fat was evident in the LnT2D group at similar levels to the O‐HV group (LnHV = 127 [53] cm(2), O‐HV = 181 [60] cm(2), LnT2D = 182 [99] cm(2), O‐T2D = 288 [72] cm(2); p < 0.0001). Only the O‐T2D group showed reductions in left ventricular ejection fraction (LnHV = 63% [4%], O‐HV = 63% [4%], LnT2D = 60% [5%], O‐T2D = 58% [6%]; p = 0.0008) and global longitudinal strain (LnHV = −15.1% [3.1%], O‐HV= −15.2% [3.7%], LnT2D = −13.4% [2.7%], O‐T2D = −11.1% [2.8%]; p = 0.002) compared with both control groups. CONCLUSIONS: Patients with T2D and normal body weight do not show alterations in global stress MBF, but they do show significant increases in visceral adiposity. Patients with T2D who were overweight and had no prior cardiovascular disease showed an increase in visceral adiposity and significant reductions in stress MBF. [Image: see text]
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spelling pubmed-93145972022-07-30 Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes Chowdhary, Amrit Thirunavukarasu, Sharmaine Jex, Nicholas Coles, Lauren Bowers, Charles Sengupta, Anshuman Swoboda, Peter Witte, Klaus Cubbon, Richard Xue, Hui Kellman, Peter Greenwood, John Plein, Sven Levelt, Eylem Obesity (Silver Spring) ORIGINAL ARTICLES OBJECTIVE: This study sought to assess whether diabetes affects coronary microvascular function in individuals with normal body weight. METHODS: Seventy‐five participants (30 patients with type 2 diabetes [T2D] who were overweight [O‐T2D], 15 patients with T2D who were lean [LnT2D], 15 healthy volunteers who were lean [LnHV], and 15 healthy volunteers who were overweight [O‐HV]) without established cardiovascular disease were recruited. Participants underwent magnetic resonance imaging for assessment of subcutaneous, epicardial, and visceral adipose tissue areas, adenosine stress myocardial blood flow (MBF), and cardiac structure and function. RESULTS: Stress MBF was reduced only in the O‐T2D group (mean [SD], LnHV = 2.07 [0.47] mL/g/min, O‐HV = 2.08 [0.42] mL/g/min, LnT2D = 2.16 [0.36] mL/g/min, O‐T2D = 1.60 [0.28] mL/g/min; p ≤ 0.0001). Accumulation of visceral fat was evident in the LnT2D group at similar levels to the O‐HV group (LnHV = 127 [53] cm(2), O‐HV = 181 [60] cm(2), LnT2D = 182 [99] cm(2), O‐T2D = 288 [72] cm(2); p < 0.0001). Only the O‐T2D group showed reductions in left ventricular ejection fraction (LnHV = 63% [4%], O‐HV = 63% [4%], LnT2D = 60% [5%], O‐T2D = 58% [6%]; p = 0.0008) and global longitudinal strain (LnHV = −15.1% [3.1%], O‐HV= −15.2% [3.7%], LnT2D = −13.4% [2.7%], O‐T2D = −11.1% [2.8%]; p = 0.002) compared with both control groups. CONCLUSIONS: Patients with T2D and normal body weight do not show alterations in global stress MBF, but they do show significant increases in visceral adiposity. Patients with T2D who were overweight and had no prior cardiovascular disease showed an increase in visceral adiposity and significant reductions in stress MBF. [Image: see text] John Wiley and Sons Inc. 2022-03-31 2022-05 /pmc/articles/PMC9314597/ /pubmed/35357083 http://dx.doi.org/10.1002/oby.23413 Text en © 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS). https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle ORIGINAL ARTICLES
Chowdhary, Amrit
Thirunavukarasu, Sharmaine
Jex, Nicholas
Coles, Lauren
Bowers, Charles
Sengupta, Anshuman
Swoboda, Peter
Witte, Klaus
Cubbon, Richard
Xue, Hui
Kellman, Peter
Greenwood, John
Plein, Sven
Levelt, Eylem
Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes
title Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes
title_full Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes
title_fullStr Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes
title_full_unstemmed Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes
title_short Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes
title_sort coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314597/
https://www.ncbi.nlm.nih.gov/pubmed/35357083
http://dx.doi.org/10.1002/oby.23413
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