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Irradiation immunity interactions
The immune system can influence cancer development by both impeding and/or facilitating tumour growth and spread. A better understanding of this complex relationship is fundamental to optimise current and future cancer therapeutic strategies. Although typically regarded as a localised and immunosupp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314628/ https://www.ncbi.nlm.nih.gov/pubmed/35261190 http://dx.doi.org/10.1111/1754-9485.13399 |
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author | Simon Davis, David A Atmosukarto, Ines I Garrett, Jessica Gosling, Katharine Syed, Farhan M Quah, Ben JC |
author_facet | Simon Davis, David A Atmosukarto, Ines I Garrett, Jessica Gosling, Katharine Syed, Farhan M Quah, Ben JC |
author_sort | Simon Davis, David A |
collection | PubMed |
description | The immune system can influence cancer development by both impeding and/or facilitating tumour growth and spread. A better understanding of this complex relationship is fundamental to optimise current and future cancer therapeutic strategies. Although typically regarded as a localised and immunosuppressive anti‐cancer treatment modality, radiation therapy has been associated with generating profound systemic effects beyond the intended target volume. These systemic effects are immune‐driven suggesting radiation therapy can enhance anti‐tumour immunosurveillance in some instances. In this review, we summarise how radiation therapy can positively and negatively affect local and systemic anti‐tumour immune responses, how co‐administration of immunotherapy with radiation therapy may help promote anti‐tumour immunity, and how the use of immune biomarkers may help steer radiation therapy‐immunotherapy personalisation to optimise clinical outcomes. |
format | Online Article Text |
id | pubmed-9314628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93146282022-07-30 Irradiation immunity interactions Simon Davis, David A Atmosukarto, Ines I Garrett, Jessica Gosling, Katharine Syed, Farhan M Quah, Ben JC J Med Imaging Radiat Oncol RADIATION ONCOLOGY The immune system can influence cancer development by both impeding and/or facilitating tumour growth and spread. A better understanding of this complex relationship is fundamental to optimise current and future cancer therapeutic strategies. Although typically regarded as a localised and immunosuppressive anti‐cancer treatment modality, radiation therapy has been associated with generating profound systemic effects beyond the intended target volume. These systemic effects are immune‐driven suggesting radiation therapy can enhance anti‐tumour immunosurveillance in some instances. In this review, we summarise how radiation therapy can positively and negatively affect local and systemic anti‐tumour immune responses, how co‐administration of immunotherapy with radiation therapy may help promote anti‐tumour immunity, and how the use of immune biomarkers may help steer radiation therapy‐immunotherapy personalisation to optimise clinical outcomes. John Wiley and Sons Inc. 2022-03-08 2022-06 /pmc/articles/PMC9314628/ /pubmed/35261190 http://dx.doi.org/10.1111/1754-9485.13399 Text en © 2022 The Authors. Journal of Medical Imaging and Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Radiologists. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RADIATION ONCOLOGY Simon Davis, David A Atmosukarto, Ines I Garrett, Jessica Gosling, Katharine Syed, Farhan M Quah, Ben JC Irradiation immunity interactions |
title | Irradiation immunity interactions |
title_full | Irradiation immunity interactions |
title_fullStr | Irradiation immunity interactions |
title_full_unstemmed | Irradiation immunity interactions |
title_short | Irradiation immunity interactions |
title_sort | irradiation immunity interactions |
topic | RADIATION ONCOLOGY |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314628/ https://www.ncbi.nlm.nih.gov/pubmed/35261190 http://dx.doi.org/10.1111/1754-9485.13399 |
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