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Irradiation immunity interactions

The immune system can influence cancer development by both impeding and/or facilitating tumour growth and spread. A better understanding of this complex relationship is fundamental to optimise current and future cancer therapeutic strategies. Although typically regarded as a localised and immunosupp...

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Detalles Bibliográficos
Autores principales: Simon Davis, David A, Atmosukarto, Ines I, Garrett, Jessica, Gosling, Katharine, Syed, Farhan M, Quah, Ben JC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314628/
https://www.ncbi.nlm.nih.gov/pubmed/35261190
http://dx.doi.org/10.1111/1754-9485.13399
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author Simon Davis, David A
Atmosukarto, Ines I
Garrett, Jessica
Gosling, Katharine
Syed, Farhan M
Quah, Ben JC
author_facet Simon Davis, David A
Atmosukarto, Ines I
Garrett, Jessica
Gosling, Katharine
Syed, Farhan M
Quah, Ben JC
author_sort Simon Davis, David A
collection PubMed
description The immune system can influence cancer development by both impeding and/or facilitating tumour growth and spread. A better understanding of this complex relationship is fundamental to optimise current and future cancer therapeutic strategies. Although typically regarded as a localised and immunosuppressive anti‐cancer treatment modality, radiation therapy has been associated with generating profound systemic effects beyond the intended target volume. These systemic effects are immune‐driven suggesting radiation therapy can enhance anti‐tumour immunosurveillance in some instances. In this review, we summarise how radiation therapy can positively and negatively affect local and systemic anti‐tumour immune responses, how co‐administration of immunotherapy with radiation therapy may help promote anti‐tumour immunity, and how the use of immune biomarkers may help steer radiation therapy‐immunotherapy personalisation to optimise clinical outcomes.
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spelling pubmed-93146282022-07-30 Irradiation immunity interactions Simon Davis, David A Atmosukarto, Ines I Garrett, Jessica Gosling, Katharine Syed, Farhan M Quah, Ben JC J Med Imaging Radiat Oncol RADIATION ONCOLOGY The immune system can influence cancer development by both impeding and/or facilitating tumour growth and spread. A better understanding of this complex relationship is fundamental to optimise current and future cancer therapeutic strategies. Although typically regarded as a localised and immunosuppressive anti‐cancer treatment modality, radiation therapy has been associated with generating profound systemic effects beyond the intended target volume. These systemic effects are immune‐driven suggesting radiation therapy can enhance anti‐tumour immunosurveillance in some instances. In this review, we summarise how radiation therapy can positively and negatively affect local and systemic anti‐tumour immune responses, how co‐administration of immunotherapy with radiation therapy may help promote anti‐tumour immunity, and how the use of immune biomarkers may help steer radiation therapy‐immunotherapy personalisation to optimise clinical outcomes. John Wiley and Sons Inc. 2022-03-08 2022-06 /pmc/articles/PMC9314628/ /pubmed/35261190 http://dx.doi.org/10.1111/1754-9485.13399 Text en © 2022 The Authors. Journal of Medical Imaging and Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Radiologists. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RADIATION ONCOLOGY
Simon Davis, David A
Atmosukarto, Ines I
Garrett, Jessica
Gosling, Katharine
Syed, Farhan M
Quah, Ben JC
Irradiation immunity interactions
title Irradiation immunity interactions
title_full Irradiation immunity interactions
title_fullStr Irradiation immunity interactions
title_full_unstemmed Irradiation immunity interactions
title_short Irradiation immunity interactions
title_sort irradiation immunity interactions
topic RADIATION ONCOLOGY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314628/
https://www.ncbi.nlm.nih.gov/pubmed/35261190
http://dx.doi.org/10.1111/1754-9485.13399
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