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IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic
Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 cytokines are crucial for immune and inflammatory responses. Abnormal levels of IL-36 cytokine expression are involved in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314646/ https://www.ncbi.nlm.nih.gov/pubmed/35903102 http://dx.doi.org/10.3389/fimmu.2022.921275 |
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author | Dong, Hongna Hao, Yuqiu Li, Wei Yang, Wei Gao, Peng |
author_facet | Dong, Hongna Hao, Yuqiu Li, Wei Yang, Wei Gao, Peng |
author_sort | Dong, Hongna |
collection | PubMed |
description | Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 cytokines are crucial for immune and inflammatory responses. Abnormal levels of IL-36 cytokine expression are involved in the pathogenesis of inflammation, autoimmunity, allergy and cancer. The present study provides a summary of recent reports on IL-36 cytokines that participate in the pathogenesis of inflammatory diseases, and the potential mechanisms underlying their roles in asthma. Abnormal levels of IL-36 cytokines are associated with the pathogenesis of different types of asthma through the regulation of the functions of different types of cells. Considering the important role of IL-36 cytokines in asthma, these may become a potential therapeutic target for asthma treatment. However, existing evidence is insufficient to fully elucidate the specific mechanism underlying the action of IL-36 cytokines during the pathological process of asthma. The possible mechanisms and functions of IL-36 cytokines in different types of asthma require further studies. |
format | Online Article Text |
id | pubmed-9314646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93146462022-07-27 IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic Dong, Hongna Hao, Yuqiu Li, Wei Yang, Wei Gao, Peng Front Immunol Immunology Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 cytokines are crucial for immune and inflammatory responses. Abnormal levels of IL-36 cytokine expression are involved in the pathogenesis of inflammation, autoimmunity, allergy and cancer. The present study provides a summary of recent reports on IL-36 cytokines that participate in the pathogenesis of inflammatory diseases, and the potential mechanisms underlying their roles in asthma. Abnormal levels of IL-36 cytokines are associated with the pathogenesis of different types of asthma through the regulation of the functions of different types of cells. Considering the important role of IL-36 cytokines in asthma, these may become a potential therapeutic target for asthma treatment. However, existing evidence is insufficient to fully elucidate the specific mechanism underlying the action of IL-36 cytokines during the pathological process of asthma. The possible mechanisms and functions of IL-36 cytokines in different types of asthma require further studies. Frontiers Media S.A. 2022-07-12 /pmc/articles/PMC9314646/ /pubmed/35903102 http://dx.doi.org/10.3389/fimmu.2022.921275 Text en Copyright © 2022 Dong, Hao, Li, Yang and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Dong, Hongna Hao, Yuqiu Li, Wei Yang, Wei Gao, Peng IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic |
title | IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic |
title_full | IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic |
title_fullStr | IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic |
title_full_unstemmed | IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic |
title_short | IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic |
title_sort | il-36 cytokines: their roles in asthma and potential as a therapeutic |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314646/ https://www.ncbi.nlm.nih.gov/pubmed/35903102 http://dx.doi.org/10.3389/fimmu.2022.921275 |
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