Cargando…
The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk
Rigorous behavioral analysis is essential to the translation of research conducted using animal models of neuropsychiatric disease. Here we discuss the use of operant paradigms within our lab as a powerful approach for exploring the biobehavioral bases of disease in the maternal immune activation ra...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314699/ https://www.ncbi.nlm.nih.gov/pubmed/35319781 http://dx.doi.org/10.1002/jeab.753 |
_version_ | 1784754379996266496 |
---|---|
author | Deane, Ashley R. Ward, Ryan D. |
author_facet | Deane, Ashley R. Ward, Ryan D. |
author_sort | Deane, Ashley R. |
collection | PubMed |
description | Rigorous behavioral analysis is essential to the translation of research conducted using animal models of neuropsychiatric disease. Here we discuss the use of operant paradigms within our lab as a powerful approach for exploring the biobehavioral bases of disease in the maternal immune activation rat model of schizophrenia. We have investigated a range of disease features in schizophrenia including abnormal perception of time, cognition, learning, motivation, and internal state (psychosis), providing complex insights into brain and behavior. Beyond simple phenotyping, implementing sophisticated operant procedures has been effective in delineating aspects of pathological behavior, identifying interacting pathologies, and isolating contributing mechanisms of disease. We provide comment on the strengths of operant techniques to support high‐quality behavioral investigations in fundamental neuropsychiatric research. |
format | Online Article Text |
id | pubmed-9314699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wiley Subscription Services, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93146992022-07-30 The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk Deane, Ashley R. Ward, Ryan D. J Exp Anal Behav Review Article Rigorous behavioral analysis is essential to the translation of research conducted using animal models of neuropsychiatric disease. Here we discuss the use of operant paradigms within our lab as a powerful approach for exploring the biobehavioral bases of disease in the maternal immune activation rat model of schizophrenia. We have investigated a range of disease features in schizophrenia including abnormal perception of time, cognition, learning, motivation, and internal state (psychosis), providing complex insights into brain and behavior. Beyond simple phenotyping, implementing sophisticated operant procedures has been effective in delineating aspects of pathological behavior, identifying interacting pathologies, and isolating contributing mechanisms of disease. We provide comment on the strengths of operant techniques to support high‐quality behavioral investigations in fundamental neuropsychiatric research. Wiley Subscription Services, Inc. 2022-03-23 2022-05 /pmc/articles/PMC9314699/ /pubmed/35319781 http://dx.doi.org/10.1002/jeab.753 Text en © 2022 The Authors. Journal of the Experimental Analysis of Behavior published by Wiley Periodicals LLC on behalf of Society for the Experimental Analysis of Behavior. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Article Deane, Ashley R. Ward, Ryan D. The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk |
title | The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk |
title_full | The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk |
title_fullStr | The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk |
title_full_unstemmed | The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk |
title_short | The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk |
title_sort | instrumental role of operant paradigms in translational psychiatric research: insights from a maternal immune activation model of schizophrenia risk |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314699/ https://www.ncbi.nlm.nih.gov/pubmed/35319781 http://dx.doi.org/10.1002/jeab.753 |
work_keys_str_mv | AT deaneashleyr theinstrumentalroleofoperantparadigmsintranslationalpsychiatricresearchinsightsfromamaternalimmuneactivationmodelofschizophreniarisk AT wardryand theinstrumentalroleofoperantparadigmsintranslationalpsychiatricresearchinsightsfromamaternalimmuneactivationmodelofschizophreniarisk AT deaneashleyr instrumentalroleofoperantparadigmsintranslationalpsychiatricresearchinsightsfromamaternalimmuneactivationmodelofschizophreniarisk AT wardryand instrumentalroleofoperantparadigmsintranslationalpsychiatricresearchinsightsfromamaternalimmuneactivationmodelofschizophreniarisk |