The Origin and Evolution of Bladder Cancer Stem Cells

Bladder cancer is the most common malignant tumor of the urinary system. Bladder cancer stem cells (BCSCs) play key roles in tumor initiation, metastasis, relapse and drug-resistance. Investigation of BCSCs is of great value. On the basis of a review of normal bladder stem cells and universal cancer...

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Autores principales: Tan, Jiufeng, Wang, Yao, Sun, Lihui, Xu, Siqi, Li, Charles, Jin, Xuefei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314767/
https://www.ncbi.nlm.nih.gov/pubmed/35903544
http://dx.doi.org/10.3389/fcell.2022.950241
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author Tan, Jiufeng
Wang, Yao
Sun, Lihui
Xu, Siqi
Li, Charles
Jin, Xuefei
author_facet Tan, Jiufeng
Wang, Yao
Sun, Lihui
Xu, Siqi
Li, Charles
Jin, Xuefei
author_sort Tan, Jiufeng
collection PubMed
description Bladder cancer is the most common malignant tumor of the urinary system. Bladder cancer stem cells (BCSCs) play key roles in tumor initiation, metastasis, relapse and drug-resistance. Investigation of BCSCs is of great value. On the basis of a review of normal bladder stem cells and universal cancer stem cells (CSCs), we summarize the origin of BCSCs, isolation and identification of CSCs from bladder cancer, signaling pathway of BCSCs, BCSCs targeted therapy, and relationship of BCSCs with non-muscle invasiveness and muscle invasiveness. This review aims to provide better elucidation about BCSCs, and provide constructive data for classification, prognosis, treatment and early intervention of bladder cancer.
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spelling pubmed-93147672022-07-27 The Origin and Evolution of Bladder Cancer Stem Cells Tan, Jiufeng Wang, Yao Sun, Lihui Xu, Siqi Li, Charles Jin, Xuefei Front Cell Dev Biol Cell and Developmental Biology Bladder cancer is the most common malignant tumor of the urinary system. Bladder cancer stem cells (BCSCs) play key roles in tumor initiation, metastasis, relapse and drug-resistance. Investigation of BCSCs is of great value. On the basis of a review of normal bladder stem cells and universal cancer stem cells (CSCs), we summarize the origin of BCSCs, isolation and identification of CSCs from bladder cancer, signaling pathway of BCSCs, BCSCs targeted therapy, and relationship of BCSCs with non-muscle invasiveness and muscle invasiveness. This review aims to provide better elucidation about BCSCs, and provide constructive data for classification, prognosis, treatment and early intervention of bladder cancer. Frontiers Media S.A. 2022-07-12 /pmc/articles/PMC9314767/ /pubmed/35903544 http://dx.doi.org/10.3389/fcell.2022.950241 Text en Copyright © 2022 Tan, Wang, Sun, Xu, Li and Jin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tan, Jiufeng
Wang, Yao
Sun, Lihui
Xu, Siqi
Li, Charles
Jin, Xuefei
The Origin and Evolution of Bladder Cancer Stem Cells
title The Origin and Evolution of Bladder Cancer Stem Cells
title_full The Origin and Evolution of Bladder Cancer Stem Cells
title_fullStr The Origin and Evolution of Bladder Cancer Stem Cells
title_full_unstemmed The Origin and Evolution of Bladder Cancer Stem Cells
title_short The Origin and Evolution of Bladder Cancer Stem Cells
title_sort origin and evolution of bladder cancer stem cells
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314767/
https://www.ncbi.nlm.nih.gov/pubmed/35903544
http://dx.doi.org/10.3389/fcell.2022.950241
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