Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer

Loss‐of‐function mutations in RNF43 induce activation of Wnt ligand‐dependent Wnt/β‐catenin signaling through stabilization of the Frizzled receptor, which is often found in microsatellite instability (MSI)‐type colorectal cancer (CRC) that develops from sessile serrated adenomas. However, the mecha...

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Detalles Bibliográficos
Autores principales: Yamamoto, Daisuke, Oshima, Hiroko, Wang, Dong, Takeda, Haruna, Kita, Kenji, Lei, Xuelian, Nakayama, Mizuho, Murakami, Kazuhiro, Ohama, Takashi, Takemura, Hirofumi, Toyota, Mutsumi, Suzuki, Hiromu, Inaki, Noriyuki, Oshima, Masanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314865/
https://www.ncbi.nlm.nih.gov/pubmed/35040131
http://dx.doi.org/10.1002/path.5868

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