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Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease
NEW FINDINGS: What is the central question of this study? We determined whether sensory feedback from metabolically sensitive skeletal muscle afferents (metaboreflex) causes a greater ventilatory response and higher dyspnoea ratings in fibrosing interstitial lung disease (FILD). What is the main fin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314965/ https://www.ncbi.nlm.nih.gov/pubmed/35298060 http://dx.doi.org/10.1113/EP090252 |
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author | Chen, Charlotte Kolbe, John Wilsher, Margaret L. De Boer, Sally Paton, Julian F. R. Fisher, James P. |
author_facet | Chen, Charlotte Kolbe, John Wilsher, Margaret L. De Boer, Sally Paton, Julian F. R. Fisher, James P. |
author_sort | Chen, Charlotte |
collection | PubMed |
description | NEW FINDINGS: What is the central question of this study? We determined whether sensory feedback from metabolically sensitive skeletal muscle afferents (metaboreflex) causes a greater ventilatory response and higher dyspnoea ratings in fibrosing interstitial lung disease (FILD). What is the main finding and its importance? Ventilatory responses and dyspnoea ratings during handgrip exercise and metaboreflex isolation were not different in FILD and control groups. Blood pressure and heart rate responses to handgrip were attenuated in FILD but not different to controls during metaboreflex isolation. These findings suggest that the muscle metaboreflex contribution to the respiratory response to exercise is not altered in FILD. ABSTRACT: Exercise limitation and dyspnoea are hallmarks of fibrosing interstitial lung disease (FILD); however, the physiological mechanisms are poorly understood. In other respiratory diseases, there is evidence that an augmented muscle metaboreflex may be implicated. We hypothesized that metaboreflex activation in FILD would result in elevated ventilation and dyspnoea ratings compared to healthy controls, due to augmented muscle metaboreflex. Sixteen FILD patients (three women, 69±14 years; mean±SD) and 16 age‐matched controls (four women, 67±7 years) were recruited. In a randomized cross‐over design, participants completed two min of rhythmic handgrip followed by either (i) two min of post‐exercise circulatory occlusion (PECO trial) to isolate muscle metaboreflex activation, or (ii) rested for four min (Control trial). Minute ventilation ([Formula: see text]; pneumotachometer), dyspnoea ratings (0–10 Borg scale), mean arterial pressure (MAP; finger photoplethysmography) and heart rate (HR; electrocardiogram) were measured. [Formula: see text] was higher in the FILD group at baseline and exercise increased [Formula: see text] similarly in both groups. [Formula: see text] remained elevated during PECO, but there was no between‐group difference in the magnitude of this response (Δ [Formula: see text] FILD 4.2 ± 2.5 L·min(–1) vs. controls 3.6 ± 2.4 L·min(–1), P = 0.596). At the end of PECO, dyspnoea ratings in FILD were similar to controls (1.0 ± 1.3 units vs. 0.5 ± 1.1 units). Exercise increased MAP and HR (P < 0.05) in both groups; however, responses were lower in FILD. Collectively, these findings suggest that there is not an augmented effect of the muscle metaboreflex on breathing and dyspnoea in FILD, but haemodynamic responses to handgrip are reduced relative to controls. |
format | Online Article Text |
id | pubmed-9314965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93149652022-07-30 Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease Chen, Charlotte Kolbe, John Wilsher, Margaret L. De Boer, Sally Paton, Julian F. R. Fisher, James P. Exp Physiol Research Articles NEW FINDINGS: What is the central question of this study? We determined whether sensory feedback from metabolically sensitive skeletal muscle afferents (metaboreflex) causes a greater ventilatory response and higher dyspnoea ratings in fibrosing interstitial lung disease (FILD). What is the main finding and its importance? Ventilatory responses and dyspnoea ratings during handgrip exercise and metaboreflex isolation were not different in FILD and control groups. Blood pressure and heart rate responses to handgrip were attenuated in FILD but not different to controls during metaboreflex isolation. These findings suggest that the muscle metaboreflex contribution to the respiratory response to exercise is not altered in FILD. ABSTRACT: Exercise limitation and dyspnoea are hallmarks of fibrosing interstitial lung disease (FILD); however, the physiological mechanisms are poorly understood. In other respiratory diseases, there is evidence that an augmented muscle metaboreflex may be implicated. We hypothesized that metaboreflex activation in FILD would result in elevated ventilation and dyspnoea ratings compared to healthy controls, due to augmented muscle metaboreflex. Sixteen FILD patients (three women, 69±14 years; mean±SD) and 16 age‐matched controls (four women, 67±7 years) were recruited. In a randomized cross‐over design, participants completed two min of rhythmic handgrip followed by either (i) two min of post‐exercise circulatory occlusion (PECO trial) to isolate muscle metaboreflex activation, or (ii) rested for four min (Control trial). Minute ventilation ([Formula: see text]; pneumotachometer), dyspnoea ratings (0–10 Borg scale), mean arterial pressure (MAP; finger photoplethysmography) and heart rate (HR; electrocardiogram) were measured. [Formula: see text] was higher in the FILD group at baseline and exercise increased [Formula: see text] similarly in both groups. [Formula: see text] remained elevated during PECO, but there was no between‐group difference in the magnitude of this response (Δ [Formula: see text] FILD 4.2 ± 2.5 L·min(–1) vs. controls 3.6 ± 2.4 L·min(–1), P = 0.596). At the end of PECO, dyspnoea ratings in FILD were similar to controls (1.0 ± 1.3 units vs. 0.5 ± 1.1 units). Exercise increased MAP and HR (P < 0.05) in both groups; however, responses were lower in FILD. Collectively, these findings suggest that there is not an augmented effect of the muscle metaboreflex on breathing and dyspnoea in FILD, but haemodynamic responses to handgrip are reduced relative to controls. John Wiley and Sons Inc. 2022-03-30 2022-05-01 /pmc/articles/PMC9314965/ /pubmed/35298060 http://dx.doi.org/10.1113/EP090252 Text en © 2022 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Chen, Charlotte Kolbe, John Wilsher, Margaret L. De Boer, Sally Paton, Julian F. R. Fisher, James P. Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease |
title | Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease |
title_full | Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease |
title_fullStr | Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease |
title_full_unstemmed | Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease |
title_short | Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease |
title_sort | cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314965/ https://www.ncbi.nlm.nih.gov/pubmed/35298060 http://dx.doi.org/10.1113/EP090252 |
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