Cargando…
Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization
OBJECTIVE: Bilateral synchronous cortical activity occurs during sleep, attention, and seizures. Canonical models place the thalamus at the center of bilateral cortical synchronization because it generates bilateral sleep spindle oscillations and primarily generalized absence seizures. However, clas...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315027/ https://www.ncbi.nlm.nih.gov/pubmed/35226367 http://dx.doi.org/10.1002/ana.26338 |
_version_ | 1784754461155000320 |
---|---|
author | Brodovskaya, Anastasia Batabyal, Tamal Shiono, Shinnosuke Sun, Huayu Kapur, Jaideep |
author_facet | Brodovskaya, Anastasia Batabyal, Tamal Shiono, Shinnosuke Sun, Huayu Kapur, Jaideep |
author_sort | Brodovskaya, Anastasia |
collection | PubMed |
description | OBJECTIVE: Bilateral synchronous cortical activity occurs during sleep, attention, and seizures. Canonical models place the thalamus at the center of bilateral cortical synchronization because it generates bilateral sleep spindle oscillations and primarily generalized absence seizures. However, classical studies suggest that the corpus callosum mediates bilateral cortical synchronization. METHODS: We mapped the spread of right frontal lobe‐onset, focal to bilateral seizures in mice and modified it using chemo and optogenetic suppression of motor thalamic nucleus and corpus callosotomy. RESULTS: Seizures from the right cortex spread faster to the left cortex than to the left thalamus. The 2 thalami have minimal monosynaptic commissural connections compared to the massive commissure corpus callosum. Chemogenetic and closed‐loop optogenetic inhibition of the right ventrolateral thalamic nucleus did not alter inter‐hemispheric seizure spread. However, anterior callosotomy delayed bilateral seizure oscillations. INTERPRETATION: Thalamocortical oscillations amplify focal onset motor seizures, and corpus callosum spreads them bilaterally. ANN NEUROL 2022;91:682–696 |
format | Online Article Text |
id | pubmed-9315027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93150272022-07-30 Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization Brodovskaya, Anastasia Batabyal, Tamal Shiono, Shinnosuke Sun, Huayu Kapur, Jaideep Ann Neurol Research Articles OBJECTIVE: Bilateral synchronous cortical activity occurs during sleep, attention, and seizures. Canonical models place the thalamus at the center of bilateral cortical synchronization because it generates bilateral sleep spindle oscillations and primarily generalized absence seizures. However, classical studies suggest that the corpus callosum mediates bilateral cortical synchronization. METHODS: We mapped the spread of right frontal lobe‐onset, focal to bilateral seizures in mice and modified it using chemo and optogenetic suppression of motor thalamic nucleus and corpus callosotomy. RESULTS: Seizures from the right cortex spread faster to the left cortex than to the left thalamus. The 2 thalami have minimal monosynaptic commissural connections compared to the massive commissure corpus callosum. Chemogenetic and closed‐loop optogenetic inhibition of the right ventrolateral thalamic nucleus did not alter inter‐hemispheric seizure spread. However, anterior callosotomy delayed bilateral seizure oscillations. INTERPRETATION: Thalamocortical oscillations amplify focal onset motor seizures, and corpus callosum spreads them bilaterally. ANN NEUROL 2022;91:682–696 John Wiley & Sons, Inc. 2022-03-12 2022-05 /pmc/articles/PMC9315027/ /pubmed/35226367 http://dx.doi.org/10.1002/ana.26338 Text en © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Brodovskaya, Anastasia Batabyal, Tamal Shiono, Shinnosuke Sun, Huayu Kapur, Jaideep Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization |
title | Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization |
title_full | Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization |
title_fullStr | Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization |
title_full_unstemmed | Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization |
title_short | Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization |
title_sort | distinct roles of rodent thalamus and corpus callosum in seizure generalization |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315027/ https://www.ncbi.nlm.nih.gov/pubmed/35226367 http://dx.doi.org/10.1002/ana.26338 |
work_keys_str_mv | AT brodovskayaanastasia distinctrolesofrodentthalamusandcorpuscallosuminseizuregeneralization AT batabyaltamal distinctrolesofrodentthalamusandcorpuscallosuminseizuregeneralization AT shionoshinnosuke distinctrolesofrodentthalamusandcorpuscallosuminseizuregeneralization AT sunhuayu distinctrolesofrodentthalamusandcorpuscallosuminseizuregeneralization AT kapurjaideep distinctrolesofrodentthalamusandcorpuscallosuminseizuregeneralization |