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Conformationally Constrained Sialyl Analogues as New Potential Binders of h‐CD22

Here, two conformationally constrained sialyl analogues were synthesized and characterized in their interaction with the inhibitory Siglec, human CD22 (h‐CD22). An orthogonal approach, including biophysical assays (SPR and fluorescence), ligand‐based NMR techniques, and molecular modelling, was empl...

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Detalles Bibliográficos
Autores principales:	Forgione, Rosa Ester, Nieto, Ferran Fabregat, Di Carluccio, Cristina, Milanesi, Francesco, Fruscella, Martina, Papi, Francesco, Nativi, Cristina, Molinaro, Antonio, Palladino, Pasquale, Scarano, Simona, Minunni, Maria, Montefiori, Marco, Civera, Monica, Sattin, Sara, Francesconi, Oscar, Marchetti, Roberta, Silipo, Alba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315041/ https://www.ncbi.nlm.nih.gov/pubmed/35313057 http://dx.doi.org/10.1002/cbic.202200076

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