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Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity

Drug hypersensitivity is an inflammatory or immune reaction induced by drugs. It can be fatal if not appropriately treated and cause the risk of long-term complications. Sulfonamides are classified as antimicrobial drugs with a broad spectrum effective for gram-positive and gram-negative bacteria. T...

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Autores principales: Asyraf, Pungki Afifah, Kusnadi, Ivanna Fauziyah, Stefanus, Jonathan, Khairinisa, Miski Aghnia, Abdulah, Rizky
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315057/
https://www.ncbi.nlm.nih.gov/pubmed/35903308
http://dx.doi.org/10.2147/DHPS.S347522
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author Asyraf, Pungki Afifah
Kusnadi, Ivanna Fauziyah
Stefanus, Jonathan
Khairinisa, Miski Aghnia
Abdulah, Rizky
author_facet Asyraf, Pungki Afifah
Kusnadi, Ivanna Fauziyah
Stefanus, Jonathan
Khairinisa, Miski Aghnia
Abdulah, Rizky
author_sort Asyraf, Pungki Afifah
collection PubMed
description Drug hypersensitivity is an inflammatory or immune reaction induced by drugs. It can be fatal if not appropriately treated and cause the risk of long-term complications. Sulfonamides are classified as antimicrobial drugs with a broad spectrum effective for gram-positive and gram-negative bacteria. This antibacterial agent works by competitively inhibiting folic acid synthesis, which prevents the growth and proliferation of microorganisms. In its use as antibiotics, sulfonamides can also cause adverse reactions in specific individuals. It has been widely reported that sulfonamide antimicrobials cause hypersensitivity reactions mediated by IgE or T cells. This review identifies symptoms or signs that can appear, as well as genes associated with sulfonamide hypersensitivity reactions, as sulfonamide may cause hypersensitivity in the form of uveitis, skin rash, Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), parotitis, angioedema, drug reaction with eosinophilia and systemic symptoms (DRESS), and pruritus. In addition, several genes were found to be associated with sulfonamide hypersensitivity, including HLA-A29, HLA-B12, HLA-DR7, HLA-B44, and HLA A*11:01.
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spelling pubmed-93150572022-07-27 Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity Asyraf, Pungki Afifah Kusnadi, Ivanna Fauziyah Stefanus, Jonathan Khairinisa, Miski Aghnia Abdulah, Rizky Drug Healthc Patient Saf Review Drug hypersensitivity is an inflammatory or immune reaction induced by drugs. It can be fatal if not appropriately treated and cause the risk of long-term complications. Sulfonamides are classified as antimicrobial drugs with a broad spectrum effective for gram-positive and gram-negative bacteria. This antibacterial agent works by competitively inhibiting folic acid synthesis, which prevents the growth and proliferation of microorganisms. In its use as antibiotics, sulfonamides can also cause adverse reactions in specific individuals. It has been widely reported that sulfonamide antimicrobials cause hypersensitivity reactions mediated by IgE or T cells. This review identifies symptoms or signs that can appear, as well as genes associated with sulfonamide hypersensitivity reactions, as sulfonamide may cause hypersensitivity in the form of uveitis, skin rash, Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), parotitis, angioedema, drug reaction with eosinophilia and systemic symptoms (DRESS), and pruritus. In addition, several genes were found to be associated with sulfonamide hypersensitivity, including HLA-A29, HLA-B12, HLA-DR7, HLA-B44, and HLA A*11:01. Dove 2022-07-21 /pmc/articles/PMC9315057/ /pubmed/35903308 http://dx.doi.org/10.2147/DHPS.S347522 Text en © 2022 Asyraf et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Asyraf, Pungki Afifah
Kusnadi, Ivanna Fauziyah
Stefanus, Jonathan
Khairinisa, Miski Aghnia
Abdulah, Rizky
Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity
title Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity
title_full Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity
title_fullStr Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity
title_full_unstemmed Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity
title_short Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity
title_sort clinical manifestations and genetic influences in sulfonamide-induced hypersensitivity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315057/
https://www.ncbi.nlm.nih.gov/pubmed/35903308
http://dx.doi.org/10.2147/DHPS.S347522
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