Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice

PURPOSE: Light detection in retinal rod photoreceptors is initiated by activation of the visual pigment rhodopsin. A critical, yet often-overlooked, step enabling efficient perception of light is rhodopsin dephosphorylation mediated by protein phosphatase 2A (PP2A). PP2A deficiency has been reported...

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Detalles Bibliográficos
Autores principales: Kolesnikov, Alexander V., Luu, Jennings, Jin, Hui, Palczewski, Krzysztof, Kefalov, Vladimir J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Visual Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315073/
https://www.ncbi.nlm.nih.gov/pubmed/35861670
http://dx.doi.org/10.1167/iovs.63.8.18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315073/
https://www.ncbi.nlm.nih.gov/pubmed/35861670
http://dx.doi.org/10.1167/iovs.63.8.18

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