Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380

Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F–H (1-3), along with staurosporine (4) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380. Structures of streptocarbazoles F–H were, respectively, determined...

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Autores principales: Cui, Tongxu, Lin, Simin, Wang, Zizhen, Fu, Peng, Wang, Cong, Zhu, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315148/
https://www.ncbi.nlm.nih.gov/pubmed/35903465
http://dx.doi.org/10.3389/fmicb.2022.957473
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author Cui, Tongxu
Lin, Simin
Wang, Zizhen
Fu, Peng
Wang, Cong
Zhu, Weiming
author_facet Cui, Tongxu
Lin, Simin
Wang, Zizhen
Fu, Peng
Wang, Cong
Zhu, Weiming
author_sort Cui, Tongxu
collection PubMed
description Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F–H (1-3), along with staurosporine (4) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380. Structures of streptocarbazoles F–H were, respectively, determined as N-demethyl-N-hexanoylstaurosporine (1), N-demethyl-N-(2-methyl-3-methoxypyridin-4-yl) staurosporine staurosporine (2), and 4-(N-demethylstaurosporine-N-yl)-1,2-dimethyl-3-methoxypyridinium (3) by spectroscopic analysis and electronic circular dichroism comparison with staurosporine. Compared with staurosporine (4), streptocarbazoles F–H (1-3) showed a selective antiproliferation of the acute myeloid leukemia cell line MV4-11 with the IC(50) values of 0.81, 0.55, and 1.88 μM, respectively.
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spelling pubmed-93151482022-07-27 Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380 Cui, Tongxu Lin, Simin Wang, Zizhen Fu, Peng Wang, Cong Zhu, Weiming Front Microbiol Microbiology Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F–H (1-3), along with staurosporine (4) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380. Structures of streptocarbazoles F–H were, respectively, determined as N-demethyl-N-hexanoylstaurosporine (1), N-demethyl-N-(2-methyl-3-methoxypyridin-4-yl) staurosporine staurosporine (2), and 4-(N-demethylstaurosporine-N-yl)-1,2-dimethyl-3-methoxypyridinium (3) by spectroscopic analysis and electronic circular dichroism comparison with staurosporine. Compared with staurosporine (4), streptocarbazoles F–H (1-3) showed a selective antiproliferation of the acute myeloid leukemia cell line MV4-11 with the IC(50) values of 0.81, 0.55, and 1.88 μM, respectively. Frontiers Media S.A. 2022-07-12 /pmc/articles/PMC9315148/ /pubmed/35903465 http://dx.doi.org/10.3389/fmicb.2022.957473 Text en Copyright © 2022 Cui, Lin, Wang, Fu, Wang and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Cui, Tongxu
Lin, Simin
Wang, Zizhen
Fu, Peng
Wang, Cong
Zhu, Weiming
Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
title Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
title_full Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
title_fullStr Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
title_full_unstemmed Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
title_short Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
title_sort cytotoxic indolocarbazoles from a marine-derived streptomyces sp. oucmdz-5380
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315148/
https://www.ncbi.nlm.nih.gov/pubmed/35903465
http://dx.doi.org/10.3389/fmicb.2022.957473
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