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Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation

In less agroecological parts of the Asian, Arabian, and African deserts, Camelus dromedarius play an important role in human survival. For many years, camels have been employed as a source of food, a tool of transportation, and a means of defense. They are becoming increasingly important as viable l...

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Autores principales: Kandeel, Mahmoud, Al-Taher, Abdulla, Venugopala, Katharigatta N., Marzok, Mohamed, Morsy, Mohamed, Nagaraja, Sreeharsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315206/
https://www.ncbi.nlm.nih.gov/pubmed/35903143
http://dx.doi.org/10.3389/fvets.2022.911511
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author Kandeel, Mahmoud
Al-Taher, Abdulla
Venugopala, Katharigatta N.
Marzok, Mohamed
Morsy, Mohamed
Nagaraja, Sreeharsha
author_facet Kandeel, Mahmoud
Al-Taher, Abdulla
Venugopala, Katharigatta N.
Marzok, Mohamed
Morsy, Mohamed
Nagaraja, Sreeharsha
author_sort Kandeel, Mahmoud
collection PubMed
description In less agroecological parts of the Asian, Arabian, and African deserts, Camelus dromedarius play an important role in human survival. For many years, camels have been employed as a source of food, a tool of transportation, and a means of defense. They are becoming increasingly important as viable livestock animals in many desert climates. With the help of camel genetics, genomics and proteomics known so far, this review article will summarize camel enzymes and proteins, which allow them to thrive under varied harsh environmental situations. An in-depth study of the dromedary genome revealed the existence of protein-coding and fast-developing genes that govern a variety of metabolic responses including lipid and protein metabolism, glucoamylase, flavin-containing monooxygenase and guanidinoacetate methyltransferase are other metabolic enzymes found in the small intestine, liver, pancreas, and spleen. In addition, we will discuss the handling of common medications by camel liver cytochrome p 450, which are different from human enzymes. Moreover, camels developed several paths to get optimum levels of trace elements like copper, zinc, selenium, etc., which have key importance in their body for normal regulation of metabolic events. Insulin tolerance, carbohydrate and energy metabolism, xenobiotics metabolizing enzymes, vimentin functions, behavior during the rutting season, resistance to starvation and changes in blood composition and resistance to water loss were among the attractive aspects of camel enzymes and proteins peculiarities in the camels. Resolving the enigma of the method of adaptation and the molecular processes linked with camel life is still a developing repository full of mysteries that need additional exploration.
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spelling pubmed-93152062022-07-27 Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation Kandeel, Mahmoud Al-Taher, Abdulla Venugopala, Katharigatta N. Marzok, Mohamed Morsy, Mohamed Nagaraja, Sreeharsha Front Vet Sci Veterinary Science In less agroecological parts of the Asian, Arabian, and African deserts, Camelus dromedarius play an important role in human survival. For many years, camels have been employed as a source of food, a tool of transportation, and a means of defense. They are becoming increasingly important as viable livestock animals in many desert climates. With the help of camel genetics, genomics and proteomics known so far, this review article will summarize camel enzymes and proteins, which allow them to thrive under varied harsh environmental situations. An in-depth study of the dromedary genome revealed the existence of protein-coding and fast-developing genes that govern a variety of metabolic responses including lipid and protein metabolism, glucoamylase, flavin-containing monooxygenase and guanidinoacetate methyltransferase are other metabolic enzymes found in the small intestine, liver, pancreas, and spleen. In addition, we will discuss the handling of common medications by camel liver cytochrome p 450, which are different from human enzymes. Moreover, camels developed several paths to get optimum levels of trace elements like copper, zinc, selenium, etc., which have key importance in their body for normal regulation of metabolic events. Insulin tolerance, carbohydrate and energy metabolism, xenobiotics metabolizing enzymes, vimentin functions, behavior during the rutting season, resistance to starvation and changes in blood composition and resistance to water loss were among the attractive aspects of camel enzymes and proteins peculiarities in the camels. Resolving the enigma of the method of adaptation and the molecular processes linked with camel life is still a developing repository full of mysteries that need additional exploration. Frontiers Media S.A. 2022-07-12 /pmc/articles/PMC9315206/ /pubmed/35903143 http://dx.doi.org/10.3389/fvets.2022.911511 Text en Copyright © 2022 Kandeel, Al-Taher, Venugopala, Marzok, Morsy and Nagaraja. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Kandeel, Mahmoud
Al-Taher, Abdulla
Venugopala, Katharigatta N.
Marzok, Mohamed
Morsy, Mohamed
Nagaraja, Sreeharsha
Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
title Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
title_full Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
title_fullStr Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
title_full_unstemmed Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
title_short Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
title_sort camel proteins and enzymes: a growing resource for functional evolution and environmental adaptation
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315206/
https://www.ncbi.nlm.nih.gov/pubmed/35903143
http://dx.doi.org/10.3389/fvets.2022.911511
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