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Genetic background modulates the sensitivity of Caenorhabditis elegans to the toxic effects of vehicular air pollution
Vehicular air pollution is an environmental toxicant that can have several health consequences, such as decreased respiratory and cardiovascular function and an increased incidence of age-related dementia and neurodegenerative diseases such as Alzheimer’s disease. C. elegans has been previously show...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315412/ https://www.ncbi.nlm.nih.gov/pubmed/35903775 http://dx.doi.org/10.17912/micropub.biology.000613 |
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author | Garcia Manriquez, Bailey A. Kikis, Elise A. |
author_facet | Garcia Manriquez, Bailey A. Kikis, Elise A. |
author_sort | Garcia Manriquez, Bailey A. |
collection | PubMed |
description | Vehicular air pollution is an environmental toxicant that can have several health consequences, such as decreased respiratory and cardiovascular function and an increased incidence of age-related dementia and neurodegenerative diseases such as Alzheimer’s disease. C. elegans has been previously shown to be a valuable animal model to study the effects of air pollution due to its tendency to respond to acute exposure to nano-sized particulate matter (nPM) produced by vehicular emissions. Specifically, nPM causes delayed development resulting in smaller animal size and induction of the SKN-1-mediated oxidative stress response. Here we show that various wild isolates demonstrate differential susceptibility to nPM, as measured by body size. Specifically, the Hawaiian isolate, CB4856, displayed the highest sensitivity, equivalent to its sensitivity to the potent oxidant paraquat. The findings described herein suggest that C. elegans may be a useful genetic tool for identifying nPM-susceptibility loci. |
format | Online Article Text |
id | pubmed-9315412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Caltech Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-93154122022-07-27 Genetic background modulates the sensitivity of Caenorhabditis elegans to the toxic effects of vehicular air pollution Garcia Manriquez, Bailey A. Kikis, Elise A. MicroPubl Biol New Finding Vehicular air pollution is an environmental toxicant that can have several health consequences, such as decreased respiratory and cardiovascular function and an increased incidence of age-related dementia and neurodegenerative diseases such as Alzheimer’s disease. C. elegans has been previously shown to be a valuable animal model to study the effects of air pollution due to its tendency to respond to acute exposure to nano-sized particulate matter (nPM) produced by vehicular emissions. Specifically, nPM causes delayed development resulting in smaller animal size and induction of the SKN-1-mediated oxidative stress response. Here we show that various wild isolates demonstrate differential susceptibility to nPM, as measured by body size. Specifically, the Hawaiian isolate, CB4856, displayed the highest sensitivity, equivalent to its sensitivity to the potent oxidant paraquat. The findings described herein suggest that C. elegans may be a useful genetic tool for identifying nPM-susceptibility loci. Caltech Library 2022-07-21 /pmc/articles/PMC9315412/ /pubmed/35903775 http://dx.doi.org/10.17912/micropub.biology.000613 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | New Finding Garcia Manriquez, Bailey A. Kikis, Elise A. Genetic background modulates the sensitivity of Caenorhabditis elegans to the toxic effects of vehicular air pollution |
title |
Genetic background modulates the sensitivity of
Caenorhabditis elegans
to the toxic effects of vehicular air pollution
|
title_full |
Genetic background modulates the sensitivity of
Caenorhabditis elegans
to the toxic effects of vehicular air pollution
|
title_fullStr |
Genetic background modulates the sensitivity of
Caenorhabditis elegans
to the toxic effects of vehicular air pollution
|
title_full_unstemmed |
Genetic background modulates the sensitivity of
Caenorhabditis elegans
to the toxic effects of vehicular air pollution
|
title_short |
Genetic background modulates the sensitivity of
Caenorhabditis elegans
to the toxic effects of vehicular air pollution
|
title_sort | genetic background modulates the sensitivity of
caenorhabditis elegans
to the toxic effects of vehicular air pollution |
topic | New Finding |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315412/ https://www.ncbi.nlm.nih.gov/pubmed/35903775 http://dx.doi.org/10.17912/micropub.biology.000613 |
work_keys_str_mv | AT garciamanriquezbaileya geneticbackgroundmodulatesthesensitivityofcaenorhabditiseleganstothetoxiceffectsofvehicularairpollution AT kikiselisea geneticbackgroundmodulatesthesensitivityofcaenorhabditiseleganstothetoxiceffectsofvehicularairpollution |