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Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound

Chemotherapeutic drugs are traditionally used for the treatment of cancer. However, chemodrugs generally induce side effects and decrease anticancer effects due to indiscriminate diffusion and poor drug delivery. To overcome these limitations of chemotherapy, in this study, ultrasound-responsive lip...

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Autores principales: Kim, Yoon-Seok, Ko, Min Jung, Moon, Hyungwon, Sim, Wonchul, Cho, Ae Shin, Gil, Gio, Kim, Hyun Ryoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315635/
https://www.ncbi.nlm.nih.gov/pubmed/35890210
http://dx.doi.org/10.3390/pharmaceutics14071314
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author Kim, Yoon-Seok
Ko, Min Jung
Moon, Hyungwon
Sim, Wonchul
Cho, Ae Shin
Gil, Gio
Kim, Hyun Ryoung
author_facet Kim, Yoon-Seok
Ko, Min Jung
Moon, Hyungwon
Sim, Wonchul
Cho, Ae Shin
Gil, Gio
Kim, Hyun Ryoung
author_sort Kim, Yoon-Seok
collection PubMed
description Chemotherapeutic drugs are traditionally used for the treatment of cancer. However, chemodrugs generally induce side effects and decrease anticancer effects due to indiscriminate diffusion and poor drug delivery. To overcome these limitations of chemotherapy, in this study, ultrasound-responsive liposomes were fabricated and used as drug carriers for delivering the anticancer drug doxorubicin, which was able to induce cancer cell death. The ultrasound-sensitive liposome demonstrated a size distribution of 81.94 nm, and the entrapment efficiency of doxorubicin was 97.1 ± 1.44%. The release of doxorubicin under the ultrasound irradiation was 60% on continuous wave and 50% by optimizing the focused ultrasound conditions. In vivo fluorescence live imaging was used to visualize the doxorubicin release in the MDA-MB-231 xenografted mouse, and it was demonstrated that liposomal drugs were released in response to ultrasound irradiation of the tissue. The combination of ultrasound and liposomes suppressed tumor growth over 56% more than liposomes without ultrasound exposure and 98% more than the control group. In conclusion, this study provides a potential alternative for overcoming the previous limitations of chemotherapeutics.
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spelling pubmed-93156352022-07-27 Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound Kim, Yoon-Seok Ko, Min Jung Moon, Hyungwon Sim, Wonchul Cho, Ae Shin Gil, Gio Kim, Hyun Ryoung Pharmaceutics Article Chemotherapeutic drugs are traditionally used for the treatment of cancer. However, chemodrugs generally induce side effects and decrease anticancer effects due to indiscriminate diffusion and poor drug delivery. To overcome these limitations of chemotherapy, in this study, ultrasound-responsive liposomes were fabricated and used as drug carriers for delivering the anticancer drug doxorubicin, which was able to induce cancer cell death. The ultrasound-sensitive liposome demonstrated a size distribution of 81.94 nm, and the entrapment efficiency of doxorubicin was 97.1 ± 1.44%. The release of doxorubicin under the ultrasound irradiation was 60% on continuous wave and 50% by optimizing the focused ultrasound conditions. In vivo fluorescence live imaging was used to visualize the doxorubicin release in the MDA-MB-231 xenografted mouse, and it was demonstrated that liposomal drugs were released in response to ultrasound irradiation of the tissue. The combination of ultrasound and liposomes suppressed tumor growth over 56% more than liposomes without ultrasound exposure and 98% more than the control group. In conclusion, this study provides a potential alternative for overcoming the previous limitations of chemotherapeutics. MDPI 2022-06-21 /pmc/articles/PMC9315635/ /pubmed/35890210 http://dx.doi.org/10.3390/pharmaceutics14071314 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Yoon-Seok
Ko, Min Jung
Moon, Hyungwon
Sim, Wonchul
Cho, Ae Shin
Gil, Gio
Kim, Hyun Ryoung
Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound
title Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound
title_full Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound
title_fullStr Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound
title_full_unstemmed Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound
title_short Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound
title_sort ultrasound-responsive liposomes for targeted drug delivery combined with focused ultrasound
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315635/
https://www.ncbi.nlm.nih.gov/pubmed/35890210
http://dx.doi.org/10.3390/pharmaceutics14071314
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