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Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis
Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexame...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315658/ https://www.ncbi.nlm.nih.gov/pubmed/35890176 http://dx.doi.org/10.3390/ph15070878 |
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author | Franco-de la Torre, Lorenzo Gómez-Sánchez, Eduardo Serafín-Higuera, Nicolás Addiel Alonso-Castro, Ángel Josabad López-Verdín, Sandra Molina-Frechero, Nelly Granados-Soto, Vinicio Isiordia-Espinoza, Mario Alberto |
author_facet | Franco-de la Torre, Lorenzo Gómez-Sánchez, Eduardo Serafín-Higuera, Nicolás Addiel Alonso-Castro, Ángel Josabad López-Verdín, Sandra Molina-Frechero, Nelly Granados-Soto, Vinicio Isiordia-Espinoza, Mario Alberto |
author_sort | Franco-de la Torre, Lorenzo |
collection | PubMed |
description | Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in patients with SIP. An information search was performed using PubMed and Google Scholar. The risk of bias of the included studies was evaluated with the Cochrane Collaboration’s risk-of-bias tool. The anesthetic success rate, pain intensity (VAS), and adverse effects were extracted. Data were analyzed using the Mantel–Haenszel test and odds ratio or the inverse variance and standardized mean difference. Dexamethasone increased the anesthetic success in comparison with placebo (n = 502; p < 0.001; OR = 2.59; 95% CIs: 1.46 to 4.59). Moreover, patients who were given dexamethasone had lower pain scores at 6 h (n = 302; p < 0.001; MD= −1.43; 95% CIs: −2.28 to −0.58), 12 h (n = 302; p < 0.0001; MD = −1.65; 95% CIs: −2.39 to −0.92), and 24 h (n = 302; p < 0.0008; MD = −1.27; 95% CIs: −2.01 to −0.53) when compared with placebo. In conclusion, the systemic administration of dexamethasone increases the anesthetic success rate and improves pain management in patients with SIP. |
format | Online Article Text |
id | pubmed-9315658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93156582022-07-27 Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis Franco-de la Torre, Lorenzo Gómez-Sánchez, Eduardo Serafín-Higuera, Nicolás Addiel Alonso-Castro, Ángel Josabad López-Verdín, Sandra Molina-Frechero, Nelly Granados-Soto, Vinicio Isiordia-Espinoza, Mario Alberto Pharmaceuticals (Basel) Systematic Review Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in patients with SIP. An information search was performed using PubMed and Google Scholar. The risk of bias of the included studies was evaluated with the Cochrane Collaboration’s risk-of-bias tool. The anesthetic success rate, pain intensity (VAS), and adverse effects were extracted. Data were analyzed using the Mantel–Haenszel test and odds ratio or the inverse variance and standardized mean difference. Dexamethasone increased the anesthetic success in comparison with placebo (n = 502; p < 0.001; OR = 2.59; 95% CIs: 1.46 to 4.59). Moreover, patients who were given dexamethasone had lower pain scores at 6 h (n = 302; p < 0.001; MD= −1.43; 95% CIs: −2.28 to −0.58), 12 h (n = 302; p < 0.0001; MD = −1.65; 95% CIs: −2.39 to −0.92), and 24 h (n = 302; p < 0.0008; MD = −1.27; 95% CIs: −2.01 to −0.53) when compared with placebo. In conclusion, the systemic administration of dexamethasone increases the anesthetic success rate and improves pain management in patients with SIP. MDPI 2022-07-16 /pmc/articles/PMC9315658/ /pubmed/35890176 http://dx.doi.org/10.3390/ph15070878 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Franco-de la Torre, Lorenzo Gómez-Sánchez, Eduardo Serafín-Higuera, Nicolás Addiel Alonso-Castro, Ángel Josabad López-Verdín, Sandra Molina-Frechero, Nelly Granados-Soto, Vinicio Isiordia-Espinoza, Mario Alberto Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis |
title | Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis |
title_full | Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis |
title_fullStr | Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis |
title_full_unstemmed | Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis |
title_short | Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis |
title_sort | dexamethasone increases the anesthetic success in patients with symptomatic irreversible pulpitis: a meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315658/ https://www.ncbi.nlm.nih.gov/pubmed/35890176 http://dx.doi.org/10.3390/ph15070878 |
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