Cargando…

Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis

Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexame...

Descripción completa

Detalles Bibliográficos
Autores principales: Franco-de la Torre, Lorenzo, Gómez-Sánchez, Eduardo, Serafín-Higuera, Nicolás Addiel, Alonso-Castro, Ángel Josabad, López-Verdín, Sandra, Molina-Frechero, Nelly, Granados-Soto, Vinicio, Isiordia-Espinoza, Mario Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315658/
https://www.ncbi.nlm.nih.gov/pubmed/35890176
http://dx.doi.org/10.3390/ph15070878
_version_ 1784754616846516224
author Franco-de la Torre, Lorenzo
Gómez-Sánchez, Eduardo
Serafín-Higuera, Nicolás Addiel
Alonso-Castro, Ángel Josabad
López-Verdín, Sandra
Molina-Frechero, Nelly
Granados-Soto, Vinicio
Isiordia-Espinoza, Mario Alberto
author_facet Franco-de la Torre, Lorenzo
Gómez-Sánchez, Eduardo
Serafín-Higuera, Nicolás Addiel
Alonso-Castro, Ángel Josabad
López-Verdín, Sandra
Molina-Frechero, Nelly
Granados-Soto, Vinicio
Isiordia-Espinoza, Mario Alberto
author_sort Franco-de la Torre, Lorenzo
collection PubMed
description Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in patients with SIP. An information search was performed using PubMed and Google Scholar. The risk of bias of the included studies was evaluated with the Cochrane Collaboration’s risk-of-bias tool. The anesthetic success rate, pain intensity (VAS), and adverse effects were extracted. Data were analyzed using the Mantel–Haenszel test and odds ratio or the inverse variance and standardized mean difference. Dexamethasone increased the anesthetic success in comparison with placebo (n = 502; p < 0.001; OR = 2.59; 95% CIs: 1.46 to 4.59). Moreover, patients who were given dexamethasone had lower pain scores at 6 h (n = 302; p < 0.001; MD= −1.43; 95% CIs: −2.28 to −0.58), 12 h (n = 302; p < 0.0001; MD = −1.65; 95% CIs: −2.39 to −0.92), and 24 h (n = 302; p < 0.0008; MD = −1.27; 95% CIs: −2.01 to −0.53) when compared with placebo. In conclusion, the systemic administration of dexamethasone increases the anesthetic success rate and improves pain management in patients with SIP.
format Online
Article
Text
id pubmed-9315658
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93156582022-07-27 Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis Franco-de la Torre, Lorenzo Gómez-Sánchez, Eduardo Serafín-Higuera, Nicolás Addiel Alonso-Castro, Ángel Josabad López-Verdín, Sandra Molina-Frechero, Nelly Granados-Soto, Vinicio Isiordia-Espinoza, Mario Alberto Pharmaceuticals (Basel) Systematic Review Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in patients with SIP. An information search was performed using PubMed and Google Scholar. The risk of bias of the included studies was evaluated with the Cochrane Collaboration’s risk-of-bias tool. The anesthetic success rate, pain intensity (VAS), and adverse effects were extracted. Data were analyzed using the Mantel–Haenszel test and odds ratio or the inverse variance and standardized mean difference. Dexamethasone increased the anesthetic success in comparison with placebo (n = 502; p < 0.001; OR = 2.59; 95% CIs: 1.46 to 4.59). Moreover, patients who were given dexamethasone had lower pain scores at 6 h (n = 302; p < 0.001; MD= −1.43; 95% CIs: −2.28 to −0.58), 12 h (n = 302; p < 0.0001; MD = −1.65; 95% CIs: −2.39 to −0.92), and 24 h (n = 302; p < 0.0008; MD = −1.27; 95% CIs: −2.01 to −0.53) when compared with placebo. In conclusion, the systemic administration of dexamethasone increases the anesthetic success rate and improves pain management in patients with SIP. MDPI 2022-07-16 /pmc/articles/PMC9315658/ /pubmed/35890176 http://dx.doi.org/10.3390/ph15070878 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Franco-de la Torre, Lorenzo
Gómez-Sánchez, Eduardo
Serafín-Higuera, Nicolás Addiel
Alonso-Castro, Ángel Josabad
López-Verdín, Sandra
Molina-Frechero, Nelly
Granados-Soto, Vinicio
Isiordia-Espinoza, Mario Alberto
Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis
title Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis
title_full Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis
title_fullStr Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis
title_full_unstemmed Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis
title_short Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis
title_sort dexamethasone increases the anesthetic success in patients with symptomatic irreversible pulpitis: a meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315658/
https://www.ncbi.nlm.nih.gov/pubmed/35890176
http://dx.doi.org/10.3390/ph15070878
work_keys_str_mv AT francodelatorrelorenzo dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis
AT gomezsanchezeduardo dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis
AT serafinhigueranicolasaddiel dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis
AT alonsocastroangeljosabad dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis
AT lopezverdinsandra dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis
AT molinafrecheronelly dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis
AT granadossotovinicio dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis
AT isiordiaespinozamarioalberto dexamethasoneincreasestheanestheticsuccessinpatientswithsymptomaticirreversiblepulpitisametaanalysis