Cargando…

Extracellular Citrate Treatment Induces HIF1α Degradation and Inhibits the Growth of Low-Glycolytic Hepatocellular Carcinoma under Hypoxia

SIMPLE SUMMARY: Patients with low-glycolytic hepatocellular carcinoma (HCC) show better clinical outcomes than those with hypoxic and high-glycolytic HCC. Low-glycolytic HCCs seem to utilize carbon sources other than glucose for metabolic fuel and tumor growth. However, by increasing tumor size, its...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Seon Yoo, Kim, Dongwoo, Kim, Jisu, Ko, Hae Young, Kim, Won Jin, Park, Youngjoo, Lee, Hye Won, Han, Dai Hoon, Kim, Kyung Sik, Park, Sunghyouk, Lee, Misu, Yun, Mijin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315704/ https://www.ncbi.nlm.nih.gov/pubmed/35884416 http://dx.doi.org/10.3390/cancers14143355

Ejemplares similares

The critical role of glucose deprivation in epithelial-mesenchymal transition in hepatocellular carcinoma under hypoxia
por: Jo, Hanhee, et al.
Publicado: (2020)

Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells
por: Jo, Hanhee, et al.
Publicado: (2020)

Impact of Exogenous Treatment with Histidine on Hepatocellular Carcinoma Cells
por: Park, Yusun, et al.
Publicado: (2022)

Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
por: Kim, Dongwoo, et al.
Publicado: (2020)

NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition
por: Joo, Hyun-Yoo, et al.
Publicado: (2023)

Brusatol-Mediated Inhibition of c-Myc Increases HIF-1α Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia
por: Oh, Eun-Taex, et al.
Publicado: (2017)

NQO1 inhibits proteasome-mediated degradation of HIF-1α
por: Oh, Eun-Taex, et al.
Publicado: (2016)

Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
por: Choi, Sik-Won, et al.
Publicado: (2016)

Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia
por: Oh, Eun-Taex, et al.
Publicado: (2016)

Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells
por: Jo, HanHee, et al.
Publicado: (2020)

Hypoxia stabilizes SETDB1 to maintain genome stability
por: Park, Sungryul, et al.
Publicado: (2023)

Glycolysis on F-18 FDG PET/CT Is Superior to Amino Acid Metabolism on C-11 Methionine PET/CT in Identifying Advanced Renal Cell Carcinoma at Staging
por: Lee, Suk-Hyun, et al.
Publicado: (2021)

Suppression of HIF-1α by Valproic Acid Sustains Self-Renewal of Mouse Embryonic Stem Cells under Hypoxia In Vitro
por: Lee, Hyo-Jong, et al.
Publicado: (2012)

Integrative Korean medicine as a possible conservative treatment for mild cervical spondylotic myelopathy: One-year follow-up case report (CARE-compliant)
por: Kim, Jisu, et al.
Publicado: (2018)

O-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Effects of Interval Training Under Hypoxia on Hematological Parameters, Hemodynamic Function, and Endurance Exercise Performance in Amateur Female Runners in Korea
por: Park, Hun-Young, et al.
Publicado: (2022)

Structural insights into the elevator-like mechanism of the sodium/citrate symporter CitS
por: Kim, Ji Won, et al.
Publicado: (2017)

The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation
por: Kim, Inhyub, et al.
Publicado: (2020)

Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid
por: Diep, Yen N., et al.
Publicado: (2023)

Amorphigenin from Amorpha fruticosa L. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner
por: Lee, Ki Won, et al.
Publicado: (2022)

Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach
por: Kwon, Hyuk Nam, et al.
Publicado: (2020)

Effects of Acute Moderate Hypoxia versus Normoxia on Metabolic and Cardiac Function and Skeletal Muscle Oxygenation during Endurance Exercise at the Same Heart Rate Level
por: Park, Hun-Young, et al.
Publicado: (2022)

Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma
por: Lee, Misu, et al.
Publicado: (2018)

Plastic-inhabiting fungi in marine environments and PCL degradation activity
por: Kim, Sung Hyun, et al.
Publicado: (2022)

Senescent melanocytes driven by glycolytic changes are characterized by melanosome transport dysfunction
por: Park, Young Joon, et al.
Publicado: (2023)

The Clinical Effects of Dendropanax Morbifera on Postmenopausal Symptoms: Review Article
por: Kim, Mijin, et al.
Publicado: (2017)

Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells
por: Lee, Su Hyun, et al.
Publicado: (2022)

Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats
por: Park, Keun-Tae, et al.
Publicado: (2020)

miR-542-3p Contributes to the HK2-Mediated High Glycolytic Phenotype in Human Glioma Cells
por: Kim, Junhyung, et al.
Publicado: (2021)

Downregulated CLIP3 induces radioresistance by enhancing stemness and glycolytic flux in glioblastoma
por: Kang, Hyunkoo, et al.
Publicado: (2021)

Metabolic tumour volume on (18)F-FDG PET/CT predicts extended pathological T stages in patients with renal cell carcinoma at staging
por: Kim, Dongwoo, et al.
Publicado: (2021)

Conversion from acetate dialysate to citrate dialysate in a central delivery system for maintenance hemodialysis patients
por: Park, Eun ji, et al.
Publicado: (2019)

Clomiphene Citrate Shows Effective and Sustained Antimicrobial Activity against Mycobacterium abscessus
por: Lee, Da-Gyum, et al.
Publicado: (2021)

Effectiveness of Sodium Picosulfate/Magnesium Citrate (PICO) for Colonoscopy Preparation
por: Song, Ki Hwan, et al.
Publicado: (2014)

Pharmacokinetic Characterization of LW6, a Novel Hypoxia-Inducible Factor-1α (HIF-1α) Inhibitor in Mice
por: Lee, Ji-Yoon, et al.
Publicado: (2021)

SPHK/HIF-1α Signaling Pathway Has a Critical Role in Chrysin-Induced Anticancer Activity in Hypoxia-Induced PC-3 Cells
por: Han, Hengmin, et al.
Publicado: (2022)

Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF
por: Lee, Sae-Won, et al.
Publicado: (2012)

Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs
por: Arthur, Sophie A., et al.
Publicado: (2019)

UV Degradation and Recovery of Perovskite Solar Cells
por: Lee, Sang-Won, et al.
Publicado: (2016)

Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer
por: Lee, Myung-Shin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jd6a3p5qvp2qfvjovv9ojmjjf2