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Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges

Objectives: To conduct a review of evidence about papillomatosis/multiple papillomas (MP), its clinical and imaging presentation, the association between MP and malignancy and the management strategies that follow. Methods: A computerized literature search using PubMed and Google Scholar was perform...

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Autores principales: Rella, Rossella, Romanucci, Giovanna, Arciuolo, Damiano, Scaldaferri, Assunta, Bufi, Enida, Croce, Sebastiano, Caulo, Andrea, Tommasini, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315766/
https://www.ncbi.nlm.nih.gov/pubmed/35877642
http://dx.doi.org/10.3390/jimaging8070198
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author Rella, Rossella
Romanucci, Giovanna
Arciuolo, Damiano
Scaldaferri, Assunta
Bufi, Enida
Croce, Sebastiano
Caulo, Andrea
Tommasini, Oscar
author_facet Rella, Rossella
Romanucci, Giovanna
Arciuolo, Damiano
Scaldaferri, Assunta
Bufi, Enida
Croce, Sebastiano
Caulo, Andrea
Tommasini, Oscar
author_sort Rella, Rossella
collection PubMed
description Objectives: To conduct a review of evidence about papillomatosis/multiple papillomas (MP), its clinical and imaging presentation, the association between MP and malignancy and the management strategies that follow. Methods: A computerized literature search using PubMed and Google Scholar was performed up to January 2021 with the following search strategy: “papilloma” OR “intraductal papilloma” OR “intraductal papillary neoplasms” OR “papillomatosis” OR “papillary lesion” AND “breast”. Two authors independently conducted a search, screening and extraction of data from the eligible studies. Results: Of the 1881 articles identified, 29 articles met the inclusion criteria. The most common breast imaging methods (mammography, ultrasound) showed few specific signs of MP, and evidence about magnetic resonance imaging were weak. Regarding the association between MP and malignancy, the risk of underestimation to biopsy methods and the frequent coexistence of MP and other high-risk lesions needs to be taken into consideration. Results about the risk of developing breast carcinoma of patients affected by MP were inconsistent. Conclusions: MP is a challenge for all breast specialists, and familiarity with its features is required to make the correct diagnosis. Further studies are needed to evaluate the factors to take into account to plan management, time of follow-up and imaging methods.
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spelling pubmed-93157662022-07-27 Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges Rella, Rossella Romanucci, Giovanna Arciuolo, Damiano Scaldaferri, Assunta Bufi, Enida Croce, Sebastiano Caulo, Andrea Tommasini, Oscar J Imaging Review Objectives: To conduct a review of evidence about papillomatosis/multiple papillomas (MP), its clinical and imaging presentation, the association between MP and malignancy and the management strategies that follow. Methods: A computerized literature search using PubMed and Google Scholar was performed up to January 2021 with the following search strategy: “papilloma” OR “intraductal papilloma” OR “intraductal papillary neoplasms” OR “papillomatosis” OR “papillary lesion” AND “breast”. Two authors independently conducted a search, screening and extraction of data from the eligible studies. Results: Of the 1881 articles identified, 29 articles met the inclusion criteria. The most common breast imaging methods (mammography, ultrasound) showed few specific signs of MP, and evidence about magnetic resonance imaging were weak. Regarding the association between MP and malignancy, the risk of underestimation to biopsy methods and the frequent coexistence of MP and other high-risk lesions needs to be taken into consideration. Results about the risk of developing breast carcinoma of patients affected by MP were inconsistent. Conclusions: MP is a challenge for all breast specialists, and familiarity with its features is required to make the correct diagnosis. Further studies are needed to evaluate the factors to take into account to plan management, time of follow-up and imaging methods. MDPI 2022-07-13 /pmc/articles/PMC9315766/ /pubmed/35877642 http://dx.doi.org/10.3390/jimaging8070198 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rella, Rossella
Romanucci, Giovanna
Arciuolo, Damiano
Scaldaferri, Assunta
Bufi, Enida
Croce, Sebastiano
Caulo, Andrea
Tommasini, Oscar
Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges
title Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges
title_full Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges
title_fullStr Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges
title_full_unstemmed Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges
title_short Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges
title_sort multiple papillomas of the breast: a review of current evidence and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315766/
https://www.ncbi.nlm.nih.gov/pubmed/35877642
http://dx.doi.org/10.3390/jimaging8070198
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