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Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study

The objective of this study is to explore the real-world effectiveness of various vaccine regimens to tackle the epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant in Thailand during September–December 2021. We applied a test-negative case control study, using nat...

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Autores principales: Suphanchaimat, Rapeepong, Nittayasoot, Natthaprang, Jiraphongsa, Chuleeporn, Thammawijaya, Panithee, Bumrungwong, Punsapach, Tulyathan, Atthavit, Cheewaruangroj, Nontawit, Pittayawonganon, Chakkarat, Tharmaphornpilas, Piyanit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315782/
https://www.ncbi.nlm.nih.gov/pubmed/35891245
http://dx.doi.org/10.3390/vaccines10071080
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author Suphanchaimat, Rapeepong
Nittayasoot, Natthaprang
Jiraphongsa, Chuleeporn
Thammawijaya, Panithee
Bumrungwong, Punsapach
Tulyathan, Atthavit
Cheewaruangroj, Nontawit
Pittayawonganon, Chakkarat
Tharmaphornpilas, Piyanit
author_facet Suphanchaimat, Rapeepong
Nittayasoot, Natthaprang
Jiraphongsa, Chuleeporn
Thammawijaya, Panithee
Bumrungwong, Punsapach
Tulyathan, Atthavit
Cheewaruangroj, Nontawit
Pittayawonganon, Chakkarat
Tharmaphornpilas, Piyanit
author_sort Suphanchaimat, Rapeepong
collection PubMed
description The objective of this study is to explore the real-world effectiveness of various vaccine regimens to tackle the epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant in Thailand during September–December 2021. We applied a test-negative case control study, using nationwide records of people tested for SARS-CoV-2. Each case was matched with two controls with respect to age, detection date, and specimen collection site. A conditional logistic regression was performed. Results were presented in the form vaccine effectiveness (VE) and 95% confidence interval. A total of 1,460,458 observations were analyzed. Overall, the two-dose heterologous prime-boost, ChAdOx1 + BNT162b2 and CoronaVac + BNT162b2, manifested the largest protection level (79.9% (74.0–84.5%) and 74.7% (62.8–82.8%)) and remained stable over the whole study course. The three-dose schedules (CoronaVac + CoronaVac + ChAdOx1, and CoronaVac + CoronaVac + BNT162b2) expressed very high degree of VE estimate (above 80.0% at any time interval). Concerning severe infection, almost all regimens displayed very high VE estimate. For the two-dose schedules, heterologous prime-boost regimens seemed to have slightly better protection for severe infection relative to homologous regimens. Campaigns to expedite the rollout of third-dose booster shot should be carried out. Heterologous prime-boost regimens should be considered as an option to enhance protection for the entire population.
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spelling pubmed-93157822022-07-27 Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study Suphanchaimat, Rapeepong Nittayasoot, Natthaprang Jiraphongsa, Chuleeporn Thammawijaya, Panithee Bumrungwong, Punsapach Tulyathan, Atthavit Cheewaruangroj, Nontawit Pittayawonganon, Chakkarat Tharmaphornpilas, Piyanit Vaccines (Basel) Article The objective of this study is to explore the real-world effectiveness of various vaccine regimens to tackle the epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant in Thailand during September–December 2021. We applied a test-negative case control study, using nationwide records of people tested for SARS-CoV-2. Each case was matched with two controls with respect to age, detection date, and specimen collection site. A conditional logistic regression was performed. Results were presented in the form vaccine effectiveness (VE) and 95% confidence interval. A total of 1,460,458 observations were analyzed. Overall, the two-dose heterologous prime-boost, ChAdOx1 + BNT162b2 and CoronaVac + BNT162b2, manifested the largest protection level (79.9% (74.0–84.5%) and 74.7% (62.8–82.8%)) and remained stable over the whole study course. The three-dose schedules (CoronaVac + CoronaVac + ChAdOx1, and CoronaVac + CoronaVac + BNT162b2) expressed very high degree of VE estimate (above 80.0% at any time interval). Concerning severe infection, almost all regimens displayed very high VE estimate. For the two-dose schedules, heterologous prime-boost regimens seemed to have slightly better protection for severe infection relative to homologous regimens. Campaigns to expedite the rollout of third-dose booster shot should be carried out. Heterologous prime-boost regimens should be considered as an option to enhance protection for the entire population. MDPI 2022-07-05 /pmc/articles/PMC9315782/ /pubmed/35891245 http://dx.doi.org/10.3390/vaccines10071080 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suphanchaimat, Rapeepong
Nittayasoot, Natthaprang
Jiraphongsa, Chuleeporn
Thammawijaya, Panithee
Bumrungwong, Punsapach
Tulyathan, Atthavit
Cheewaruangroj, Nontawit
Pittayawonganon, Chakkarat
Tharmaphornpilas, Piyanit
Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study
title Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study
title_full Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study
title_fullStr Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study
title_full_unstemmed Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study
title_short Real-World Effectiveness of Mix-and-Match Vaccine Regimens against SARS-CoV-2 Delta Variant in Thailand: A Nationwide Test-Negative Matched Case-Control Study
title_sort real-world effectiveness of mix-and-match vaccine regimens against sars-cov-2 delta variant in thailand: a nationwide test-negative matched case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315782/
https://www.ncbi.nlm.nih.gov/pubmed/35891245
http://dx.doi.org/10.3390/vaccines10071080
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