Cargando…

HSPG2 Mutation Association with Immune Checkpoint Inhibitor Outcome in Melanoma and Non-Small Cell Lung Cancer

SIMPLE SUMMARY: Immune checkpoint inhibitors (ICIs) markedly improve the survival benefits of advanced melanoma and non-small cell lung cancer (NSCLC). Nevertheless, only a subset of patients could benefit from such a therapy. Novel and effective clinical biomarkers are needed to assess ICI treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wenjing, Lin, Zhijuan, Shi, Fuyan, Wang, Qiang, Kong, Yujia, Ren, Yanfeng, Lyu, Juncheng, Sheng, Chao, Li, Yuting, Qin, Hao, Wang, Suzhen, Wang, Qinghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315784/ https://www.ncbi.nlm.nih.gov/pubmed/35884556 http://dx.doi.org/10.3390/cancers14143495

Ejemplares similares

Novel Molecular Determinants of Response or Resistance to Immune Checkpoint Inhibitor Therapies in Melanoma
por: Zhang, Wenjing, et al.
Publicado: (2022)

Fatty Acid Synthase Mutations Predict Favorable Immune Checkpoint Inhibitor Outcome and Response in Melanoma and Non-Small Cell Lung Cancer Patients
por: Wang, Qinghua, et al.
Publicado: (2022)

Association of PTPRT mutations with immune checkpoint inhibitors response and outcome in melanoma and non‐small cell lung cancer
por: Zhang, Wenjing, et al.
Publicado: (2021)

Immunological and clinical immunotherapy implications of NLRP3 mutations in melanoma
por: Wang, Qinghua, et al.
Publicado: (2021)

Favorable immune checkpoint inhibitor outcome of patients with melanoma and NSCLC harboring FAT1 mutations
por: Zhang, Wenjing, et al.
Publicado: (2022)

An aging‐related signature predicts favorable outcome and immunogenicity in lung adenocarcinoma
por: Zhang, Wenjing, et al.
Publicado: (2022)

SETBP1 mutation determines sensitivity to immune checkpoint inhibitors in melanoma and NSCLC
por: An, Fengxiao, et al.
Publicado: (2023)

Sex Disparities of Genomic Determinants in Response to Immune Checkpoint Inhibitors in Melanoma
por: Shi, Fuyan, et al.
Publicado: (2021)

Identification and Validation of RELN Mutation as a Response Indicator for Immune Checkpoint Inhibitor Therapy in Melanoma and Non-Small Cell Lung Cancer
por: Li, Zhenpeng, et al.
Publicado: (2022)

Mutations in DNA damage response pathways as a potential biomarker for immune checkpoint blockade efficacy: evidence from a seven-cancer immunotherapy cohort
por: Zhang, Wenjing, et al.
Publicado: (2021)

A Novel Pathogenic HSPG2 Mutation in Schwartz–Jampel Syndrome
por: Lin, Po-Yu, et al.
Publicado: (2021)

Bioinformatic analysis identifies the immunological profile of turner syndrome with different X chromosome origins
por: Qi, Xiao, et al.
Publicado: (2023)

Modular Proteoglycan Perlecan/HSPG2: Mutations, Phenotypes, and Functions
por: Martinez, Jerahme R., et al.
Publicado: (2018)

Is HSPG2 a modifier gene for Marfan syndrome?
por: Gerdes Gyuricza, Isabela, et al.
Publicado: (2020)

The HSPG syndecan is a core organizer of cholinergic synapses
por: Zhou, Xin, et al.
Publicado: (2021)

HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas
por: Wiweger, Malgorzata I., et al.
Publicado: (2012)

HSPG2 overexpression independently predicts poor survival in patients with acute myeloid leukemia
por: Zhou, Xiaojia, et al.
Publicado: (2020)

Evolution of the Perlecan/HSPG2 Gene and Its Activation in Regenerating Nematostella vectensis
por: Warren, Curtis R., et al.
Publicado: (2015)

Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
por: Zai, Clement C., et al.
Publicado: (2018)

Novel HSPG2 Gene Mutation Causing Schwartz–Jampel Syndrome in a Moroccan Family: A Literature Review
por: Brugnoni, Raffaella, et al.
Publicado: (2023)

Rare variant of HSPG2 is not involved in the development of adolescent idiopathic scoliosis: evidence from a large-scale replication study
por: Xia, Chao, et al.
Publicado: (2019)

Discovery of HSPG2 (Perlecan) as a Therapeutic Target in Triple Negative Breast Cancer
por: Kalscheuer, Stephen, et al.
Publicado: (2019)

Perlecan/Hspg2 Deficiency Alters the Pericellular Space of the Lacunocanalicular System Surrounding Osteocytic Processes in Cortical Bone
por: Thompson, William R, et al.
Publicado: (2011)

Exome Sequencing Identifies a Rare HSPG2 Variant Associated with Familial Idiopathic Scoliosis
por: Baschal, Erin E., et al.
Publicado: (2014)

Ectopic Expression Screen Identifies Genes Affecting Drosophila Mesoderm Development Including the HSPG Trol
por: Trisnadi, Nathanie, et al.
Publicado: (2014)

Assessing the Survival Benefit of Surgery and Various Types of Radiation Therapy for Treatment of Hepatocellular Carcinoma: Evidence from the Surveillance, Epidemiology, and End Results Registries
por: Shi, Fuyan, et al.
Publicado: (2020)

The Adenovirus Type 3 Dodecahedron's RGD Loop Comprises an HSPG Binding Site That Influences Integrin Binding
por: Gout, E., et al.
Publicado: (2010)

Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish
por: Castellanos, Barbara S., et al.
Publicado: (2021)

Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process
por: Nazere, Keyoumu, et al.
Publicado: (2022)

Epidemic of chronic diseases and the related healthy lifestyle interventions in rural areas of Shandong Province, China
por: Lyu, Juncheng, et al.
Publicado: (2020)

Integrated genomic analysis identifies a genetic mutation model predicting response to immune checkpoint inhibitors in melanoma
por: Jiang, Junjie, et al.
Publicado: (2020)

CircHSPG2 absence weakens hypoxia-induced dysfunction in cardiomyocytes by targeting the miR-25-3p/PAWR axis
por: Zhao, Ying, et al.
Publicado: (2022)

NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy
por: Toncheva, D., et al.
Publicado: (2014)

ADAMTS1 and HSPG2 mRNA levels in cumulus cells are related to human oocyte quality and controlled ovarian hyperstimulation outcomes
por: Ma, Yerong, et al.
Publicado: (2020)

Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin
por: Apostolidis, Sokratis A., et al.
Publicado: (2018)

Integrated computational approach towards identification of HSPG and ACE2 mimicking moieties for SARS-CoV-2 inhibition
por: Sreekumar, Sreya, et al.
Publicado: (2022)

Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden
por: Morrison, Carl, et al.
Publicado: (2018)

An enhanced genetic mutation-based model for predicting the efficacy of immune checkpoint inhibitors in patients with melanoma
por: Pan, Chaohu, et al.
Publicado: (2023)

HSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model
por: Lee, Tong-Young, et al.
Publicado: (2010)

Association of clock-like mutational signature with immune checkpoint inhibitor outcome in patients with melanoma and NSCLC
por: Chong, Wei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hrmfkl44mgiakvika37duuo6oj