Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia

Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that are more autoreactive and more effectively transduce signals to leukemic B cells, B-cell receptor (BCR) signaling is likely at the...

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Detalles Bibliográficos
Autores principales: Kaufman, Matthew, Yan, Xiao-Jie, Li, Wentian, Ghia, Emanuela M., Langerak, Anton W., Rassenti, Laura Z., Belessi, Chrysoula, Kay, Neil E., Davi, Frederic, Byrd, John C., Pospisilova, Sarka, Brown, Jennifer R., Catherwood, Mark, Davis, Zadie, Oscier, David, Montillo, Marco, Trentin, Livio, Rosenquist, Richard, Ghia, Paolo, Barrientos, Jacqueline C., Kolitz, Jonathan E., Allen, Steven L., Rai, Kanti R., Stamatopoulos, Kostas, Kipps, Thomas J., Neuberg, Donna, Chiorazzi, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315922/
https://www.ncbi.nlm.nih.gov/pubmed/35903706
http://dx.doi.org/10.3389/fonc.2022.897280

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