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SUMOylation and Major Depressive Disorder

Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitoch...

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Autores principales: Jeoung, Seok-Won, Park, Hyun-Sun, Ryoo, Zae Young, Cho, Dong-Hyung, Lee, Hyun-Shik, Ryu, Hong-Yeoul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316168/
https://www.ncbi.nlm.nih.gov/pubmed/35887370
http://dx.doi.org/10.3390/ijms23148023
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author Jeoung, Seok-Won
Park, Hyun-Sun
Ryoo, Zae Young
Cho, Dong-Hyung
Lee, Hyun-Shik
Ryu, Hong-Yeoul
author_facet Jeoung, Seok-Won
Park, Hyun-Sun
Ryoo, Zae Young
Cho, Dong-Hyung
Lee, Hyun-Shik
Ryu, Hong-Yeoul
author_sort Jeoung, Seok-Won
collection PubMed
description Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD.
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spelling pubmed-93161682022-07-27 SUMOylation and Major Depressive Disorder Jeoung, Seok-Won Park, Hyun-Sun Ryoo, Zae Young Cho, Dong-Hyung Lee, Hyun-Shik Ryu, Hong-Yeoul Int J Mol Sci Review Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD. MDPI 2022-07-21 /pmc/articles/PMC9316168/ /pubmed/35887370 http://dx.doi.org/10.3390/ijms23148023 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jeoung, Seok-Won
Park, Hyun-Sun
Ryoo, Zae Young
Cho, Dong-Hyung
Lee, Hyun-Shik
Ryu, Hong-Yeoul
SUMOylation and Major Depressive Disorder
title SUMOylation and Major Depressive Disorder
title_full SUMOylation and Major Depressive Disorder
title_fullStr SUMOylation and Major Depressive Disorder
title_full_unstemmed SUMOylation and Major Depressive Disorder
title_short SUMOylation and Major Depressive Disorder
title_sort sumoylation and major depressive disorder
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316168/
https://www.ncbi.nlm.nih.gov/pubmed/35887370
http://dx.doi.org/10.3390/ijms23148023
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