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SUMOylation and Major Depressive Disorder
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitoch...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316168/ https://www.ncbi.nlm.nih.gov/pubmed/35887370 http://dx.doi.org/10.3390/ijms23148023 |
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author | Jeoung, Seok-Won Park, Hyun-Sun Ryoo, Zae Young Cho, Dong-Hyung Lee, Hyun-Shik Ryu, Hong-Yeoul |
author_facet | Jeoung, Seok-Won Park, Hyun-Sun Ryoo, Zae Young Cho, Dong-Hyung Lee, Hyun-Shik Ryu, Hong-Yeoul |
author_sort | Jeoung, Seok-Won |
collection | PubMed |
description | Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD. |
format | Online Article Text |
id | pubmed-9316168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93161682022-07-27 SUMOylation and Major Depressive Disorder Jeoung, Seok-Won Park, Hyun-Sun Ryoo, Zae Young Cho, Dong-Hyung Lee, Hyun-Shik Ryu, Hong-Yeoul Int J Mol Sci Review Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD. MDPI 2022-07-21 /pmc/articles/PMC9316168/ /pubmed/35887370 http://dx.doi.org/10.3390/ijms23148023 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jeoung, Seok-Won Park, Hyun-Sun Ryoo, Zae Young Cho, Dong-Hyung Lee, Hyun-Shik Ryu, Hong-Yeoul SUMOylation and Major Depressive Disorder |
title | SUMOylation and Major Depressive Disorder |
title_full | SUMOylation and Major Depressive Disorder |
title_fullStr | SUMOylation and Major Depressive Disorder |
title_full_unstemmed | SUMOylation and Major Depressive Disorder |
title_short | SUMOylation and Major Depressive Disorder |
title_sort | sumoylation and major depressive disorder |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316168/ https://www.ncbi.nlm.nih.gov/pubmed/35887370 http://dx.doi.org/10.3390/ijms23148023 |
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