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Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico
Seven medicinal plants from Chiapas, Mexico, used by Native Americans were analyzed, aiming to improve the understanding of their medicinal properties through the evaluation of various biological activities, i.e., bactericidal, antioxidant, α-glucosidase inhibition, and toxicity, to provide a scient...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316193/ https://www.ncbi.nlm.nih.gov/pubmed/35890424 http://dx.doi.org/10.3390/plants11141790 |
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author | De La Cruz-Jiménez, Liliana Hernández-Torres, Mario Alberto Monroy-García, Imelda N. Rivas-Morales, Catalina Verde-Star, María Julia Gonzalez-Villasana, Vianey Viveros-Valdez, Ezequiel |
author_facet | De La Cruz-Jiménez, Liliana Hernández-Torres, Mario Alberto Monroy-García, Imelda N. Rivas-Morales, Catalina Verde-Star, María Julia Gonzalez-Villasana, Vianey Viveros-Valdez, Ezequiel |
author_sort | De La Cruz-Jiménez, Liliana |
collection | PubMed |
description | Seven medicinal plants from Chiapas, Mexico, used by Native Americans were analyzed, aiming to improve the understanding of their medicinal properties through the evaluation of various biological activities, i.e., bactericidal, antioxidant, α-glucosidase inhibition, and toxicity, to provide a scientific basis for the management of infectious and hyperglycemic diseases in the Mexican southeast. Plant extracts were obtained from Cordia dodecandra, Gaultheria odorata, Heliotropium angiospermum, Justicia spicigera, Leucaena collinsii spp. collinsii, Tagetes nelsonii, and Talisia oliviformis through maceration techniques using methanol and chloroform (1:1). Minimum Inhibitory Concentration (MIC) was employed to determine the antibacterial activity against Staphylococcus aureus, Enterobacter faecalis, Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeuroginosa. The antiradical/antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays and antihemolytic activity using the 2,2’-Azobis(2-amidinopropane) dihydrochloride radical (APPH). The anti-α-glucosidase activity was evaluated in vitro through the chromogenic PNPG assay. The toxicity was assessed using the brine shrimp lethality assay. The highest antimicrobial activity was displayed by T. nelsonii, mainly against E. faecalis and P. aeuroginosa. The extracts of L. collinsii, J. spicigera, and T. nelsonii possess antioxidant properties with EC(50) < 50 μg/mL. J. spicigera and T. nelsonii extracts showed the highest antihemolytic activity with IC(50) < 14 μg/mL. T. nelsonii exhibited a remarkable inhibitor effect on the α-glucosidase enzyme and the greatest toxic effect on Artemia salina with IC(50) = 193 ± 20 μg/mL and LD(50) = 14 ± 1 μg/mL, respectively. According to our results, G. odorata, J. spicigera, T. nelsonii, and T. oliviformis extracts contained active antimicrobial compounds. At the same time, T. nelsonii stands to be a possible source of effective antineoplastic and antihyperglycemic compounds. |
format | Online Article Text |
id | pubmed-9316193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93161932022-07-27 Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico De La Cruz-Jiménez, Liliana Hernández-Torres, Mario Alberto Monroy-García, Imelda N. Rivas-Morales, Catalina Verde-Star, María Julia Gonzalez-Villasana, Vianey Viveros-Valdez, Ezequiel Plants (Basel) Article Seven medicinal plants from Chiapas, Mexico, used by Native Americans were analyzed, aiming to improve the understanding of their medicinal properties through the evaluation of various biological activities, i.e., bactericidal, antioxidant, α-glucosidase inhibition, and toxicity, to provide a scientific basis for the management of infectious and hyperglycemic diseases in the Mexican southeast. Plant extracts were obtained from Cordia dodecandra, Gaultheria odorata, Heliotropium angiospermum, Justicia spicigera, Leucaena collinsii spp. collinsii, Tagetes nelsonii, and Talisia oliviformis through maceration techniques using methanol and chloroform (1:1). Minimum Inhibitory Concentration (MIC) was employed to determine the antibacterial activity against Staphylococcus aureus, Enterobacter faecalis, Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeuroginosa. The antiradical/antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays and antihemolytic activity using the 2,2’-Azobis(2-amidinopropane) dihydrochloride radical (APPH). The anti-α-glucosidase activity was evaluated in vitro through the chromogenic PNPG assay. The toxicity was assessed using the brine shrimp lethality assay. The highest antimicrobial activity was displayed by T. nelsonii, mainly against E. faecalis and P. aeuroginosa. The extracts of L. collinsii, J. spicigera, and T. nelsonii possess antioxidant properties with EC(50) < 50 μg/mL. J. spicigera and T. nelsonii extracts showed the highest antihemolytic activity with IC(50) < 14 μg/mL. T. nelsonii exhibited a remarkable inhibitor effect on the α-glucosidase enzyme and the greatest toxic effect on Artemia salina with IC(50) = 193 ± 20 μg/mL and LD(50) = 14 ± 1 μg/mL, respectively. According to our results, G. odorata, J. spicigera, T. nelsonii, and T. oliviformis extracts contained active antimicrobial compounds. At the same time, T. nelsonii stands to be a possible source of effective antineoplastic and antihyperglycemic compounds. MDPI 2022-07-06 /pmc/articles/PMC9316193/ /pubmed/35890424 http://dx.doi.org/10.3390/plants11141790 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article De La Cruz-Jiménez, Liliana Hernández-Torres, Mario Alberto Monroy-García, Imelda N. Rivas-Morales, Catalina Verde-Star, María Julia Gonzalez-Villasana, Vianey Viveros-Valdez, Ezequiel Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico |
title | Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico |
title_full | Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico |
title_fullStr | Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico |
title_full_unstemmed | Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico |
title_short | Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico |
title_sort | biological activities of seven medicinal plants used in chiapas, mexico |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316193/ https://www.ncbi.nlm.nih.gov/pubmed/35890424 http://dx.doi.org/10.3390/plants11141790 |
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