Cargando…

C8orf76 Modulates Ferroptosis in Liver Cancer via Transcriptionally Up-Regulating SLC7A11

SIMPLE SUMMARY: Chromosome 8 open reading frame 76 (C8orf76), a novel gene located in the nucleus, is highly expressed in many tumor types. Here, we present novel insights into the molecular mechanism and function of C8orf76 in HCC via in vitro and in vivo assays. On the one hand, C8orf76 could play...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Duguang, Pan, Junhai, Zhang, Yiyin, Li, Yirun, Jin, Shengxi, Zhong, Cheng, Chen, Peng, Ma, Jingjing, Hu, Wendi, Fan, Xiaoxiao, Lin, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316296/ https://www.ncbi.nlm.nih.gov/pubmed/35884471 http://dx.doi.org/10.3390/cancers14143410

Ejemplares similares

Comprehensive analysis of cuproptosis-related lncRNAs for prognostic significance and immune microenvironment characterization in hepatocellular carcinoma
por: Li, Duguang, et al.
Publicado: (2023)

Immunotherapy for Hepatocellular Carcinoma: Current Limits and Prospects
por: Zhong, Cheng, et al.
Publicado: (2021)

Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis
por: Zhang, Yiyin, et al.
Publicado: (2022)

The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine
por: Li, Duguang, et al.
Publicado: (2020)

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca(2+)-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression
por: Zhong, Cheng, et al.
Publicado: (2023)

Cell membrane-coated human hair nanoparticles for precise disease therapies
por: Zhang, Yiyin, et al.
Publicado: (2022)

Global Trends in Research of Lipid Metabolism in T lymphocytes From 1985 to 2022: A Bibliometric Analysis
por: Chen, Peng, et al.
Publicado: (2022)

A Machine‐Learning‐Based Bibliometric Analysis of Cell Membrane‐Coated Nanoparticles in Biomedical Applications over the Past Eleven Years
por: Zhang, Yiyin, et al.
Publicado: (2023)

CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer
por: Zhang, Xiaoqian, et al.
Publicado: (2023)

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
por: Yang, Jingjing, et al.
Publicado: (2021)

PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer
por: Hong, Ting, et al.
Publicado: (2021)

SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer
por: Lee, Jaewang, et al.
Publicado: (2022)

Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro
por: Liu, Xiao-Yan, et al.
Publicado: (2022)

ATF3 promotes ferroptosis in sorafenib-induced cardiotoxicity by suppressing Slc7a11 expression
por: Li, Yilan, et al.
Publicado: (2022)

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes
por: Chen, Yongquan, et al.
Publicado: (2023)

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer
por: Shen, Liliang, et al.
Publicado: (2022)

Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO/SLC7A11 pathway
por: Jiang, Tianyu, et al.
Publicado: (2023)

TXNDC12 knockdown promotes ferroptosis by modulating SLC7A11 expression in glioma
por: Yu, Hao, et al.
Publicado: (2023)

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
por: Koppula, Pranavi, et al.
Publicado: (2020)

Vitamin D Promotes Ferroptosis in Colorectal Cancer Stem Cells via SLC7A11 Downregulation
por: Guo, Shuang, et al.
Publicado: (2023)

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de‐palmitoylation
por: Shi, Zhehao, et al.
Publicado: (2023)

Targeting USP8 Inhibits O‐GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT
por: Tang, Jianing, et al.
Publicado: (2023)

METTL9-SLC7A11 axis promotes hepatocellular carcinoma progression through ferroptosis inhibition
por: Bi, Fangfang, et al.
Publicado: (2023)

The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi‐omics study
por: Xu, Fangshi, et al.
Publicado: (2021)

Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
por: Wang, Yishu, et al.
Publicado: (2020)

Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11
por: Dong, Hui, et al.
Publicado: (2021)

SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma
por: Cheng, Xin, et al.
Publicado: (2022)

LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination
por: Zhang, Baofu, et al.
Publicado: (2022)

SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma
por: Chen, Qianping, et al.
Publicado: (2022)

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis
por: Feng, Lei, et al.
Publicado: (2021)

Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma
por: Fan, Xiaoxiao, et al.
Publicado: (2019)

Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis
por: Huang, Yue-bo, et al.
Publicado: (2022)

IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer
por: Zhang, Lei, et al.
Publicado: (2020)

Methylation Drives SLC2A1 Transcription and Ferroptosis Process Decreasing Autophagy Pressure in Colon Cancer
por: Zou, Junwei, et al.
Publicado: (2022)

Rotavirus-induced lncRNA SLC7A11-AS1 promotes ferroptosis by targeting cystine/glutamate antiporter xCT (SLC7A11) to facilitate virus infection
por: Banerjee, Shreya, et al.
Publicado: (2023)

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis
por: Sehm, Tina, et al.
Publicado: (2016)

Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11
por: Qiang, Zhuanzhuan, et al.
Publicado: (2020)

SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production
por: Zhao, Xiaohuan, et al.
Publicado: (2021)

SLC7A11/GPX4 Inactivation-Mediated Ferroptosis Contributes to the Pathogenesis of Triptolide-Induced Cardiotoxicity
por: Liu, Xian, et al.
Publicado: (2022)

Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer
por: Saini, Krishan Kumar, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rm4br4mtammt930t8nemlvsp0n