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Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases
SUMOylation is a post-translational modification that has emerged in recent decades as a mechanism involved in controlling diverse physiological processes and that is essential in vertebrates. The SUMO pathway is regulated by several enzymes, proteases and ligases being the main actors involved in t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316396/ https://www.ncbi.nlm.nih.gov/pubmed/35887358 http://dx.doi.org/10.3390/ijms23148012 |
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author | Lara-Ureña, Nieves Jafari, Vahid García-Domínguez, Mario |
author_facet | Lara-Ureña, Nieves Jafari, Vahid García-Domínguez, Mario |
author_sort | Lara-Ureña, Nieves |
collection | PubMed |
description | SUMOylation is a post-translational modification that has emerged in recent decades as a mechanism involved in controlling diverse physiological processes and that is essential in vertebrates. The SUMO pathway is regulated by several enzymes, proteases and ligases being the main actors involved in the control of sumoylation of specific targets. Dysregulation of the expression, localization and function of these enzymes produces physiological changes that can lead to the appearance of different types of cancer, depending on the enzymes and target proteins involved. Among the most studied proteases and ligases, those of the SENP and PIAS families stand out, respectively. While the proteases involved in this pathway have specific SUMO activity, the ligases may have additional functions unrelated to sumoylation, which makes it more difficult to study their SUMO-associated role in cancer process. In this review we update the knowledge and advances in relation to the impact of dysregulation of SUMO proteases and ligases in cancer initiation and progression. |
format | Online Article Text |
id | pubmed-9316396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93163962022-07-27 Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases Lara-Ureña, Nieves Jafari, Vahid García-Domínguez, Mario Int J Mol Sci Review SUMOylation is a post-translational modification that has emerged in recent decades as a mechanism involved in controlling diverse physiological processes and that is essential in vertebrates. The SUMO pathway is regulated by several enzymes, proteases and ligases being the main actors involved in the control of sumoylation of specific targets. Dysregulation of the expression, localization and function of these enzymes produces physiological changes that can lead to the appearance of different types of cancer, depending on the enzymes and target proteins involved. Among the most studied proteases and ligases, those of the SENP and PIAS families stand out, respectively. While the proteases involved in this pathway have specific SUMO activity, the ligases may have additional functions unrelated to sumoylation, which makes it more difficult to study their SUMO-associated role in cancer process. In this review we update the knowledge and advances in relation to the impact of dysregulation of SUMO proteases and ligases in cancer initiation and progression. MDPI 2022-07-20 /pmc/articles/PMC9316396/ /pubmed/35887358 http://dx.doi.org/10.3390/ijms23148012 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lara-Ureña, Nieves Jafari, Vahid García-Domínguez, Mario Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases |
title | Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases |
title_full | Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases |
title_fullStr | Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases |
title_full_unstemmed | Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases |
title_short | Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases |
title_sort | cancer-associated dysregulation of sumo regulators: proteases and ligases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316396/ https://www.ncbi.nlm.nih.gov/pubmed/35887358 http://dx.doi.org/10.3390/ijms23148012 |
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