Cargando…

Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic Target

SIMPLE SUMMARY: Glioma is one of the most common intracranial malignancies and is incurable due to strong aggressiveness and resistance to radiotherapy and chemotherapy. The lack of effective therapeutic targets is a major problem in current treatment. In the present study, we found that nicotinamid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Wei, Zou, Yongxiang, Cai, Zheng, Huang, Jinxiang, Hong, Xinjie, Liang, Qiang, Jin, Weilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316405/ https://www.ncbi.nlm.nih.gov/pubmed/35884600 http://dx.doi.org/10.3390/cancers14143538

Ejemplares similares

Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin
por: Zou, Yongxiang, et al.
Publicado: (2017)

Vanillin downregulates NNMT and attenuates NNMT-related resistance to 5-fluorouracil via ROS-induced cell apoptosis in colorectal cancer cells
por: Li, Guoli, et al.
Publicado: (2021)

Expression profile and prognostic value of NNMT in patients with pancreatic cancer
por: Xu, Yong, et al.
Publicado: (2016)

NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer
por: Liu, Wenxiu, et al.
Publicado: (2023)

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity
por: Gao, Yongzhi, et al.
Publicado: (2019)

Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)
por: van Haren, Matthijs J., et al.
Publicado: (2021)

NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis
por: Lu, Shounan, et al.
Publicado: (2022)

NNMT: Mean-Field Based Analysis Tools for Neuronal Network Models
por: Layer, Moritz, et al.
Publicado: (2022)

Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer
por: Liang, Tairong, et al.
Publicado: (2023)

TRIM28 is overexpressed in glioma and associated with tumor progression
por: Su, Chunhai, et al.
Publicado: (2018)

NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition
por: Wu, Changqing, et al.
Publicado: (2022)

Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression
por: Wen, Qirong, et al.
Publicado: (2023)

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
por: Ulanovskaya, Olesya A., et al.
Publicado: (2013)

Proteomics reveals NNMT as a master metabolic regulator of cancer associated fibroblasts
por: Eckert, Mark A., et al.
Publicado: (2019)

Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma
por: Zhang, Weixian, et al.
Publicado: (2022)

Female Specific Association between NNMT Gene and Schizophrenia in a Han Chinese population
por: Wang, Guo-xia, et al.
Publicado: (2014)

Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension
por: Fedorowicz, Andrzej, et al.
Publicado: (2016)

NNMT activation can contribute to the development of fatty liver disease by modulating the NAD(+) metabolism
por: Komatsu, Motoaki, et al.
Publicado: (2018)

Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT
por: Kanska, Justyna, et al.
Publicado: (2017)

High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer
por: Song, Mengmeng, et al.
Publicado: (2020)

Overexpression of CD99 is associated with tumor adaptiveness and indicates the tumor recurrence and therapeutic responses in gliomas
por: Shang, Erfei, et al.
Publicado: (2023)

Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas
por: Tsai, Chia-Kuang, et al.
Publicado: (2018)

NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation
por: Shin, Ji Hye, et al.
Publicado: (2018)

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
por: Dimet-Wiley, Andrea, et al.
Publicado: (2022)

Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis
por: Roberti, Annalisa, et al.
Publicado: (2023)

Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma
por: Wang, Xiao-Qiang, et al.
Publicado: (2015)

TTPAL promotes gastric tumorigenesis by directly targeting NNMT to activate PI3K/AKT signaling
por: Liu, Wenxiu, et al.
Publicado: (2021)

GPX8 regulates clear cell renal cell carcinoma tumorigenesis through promoting lipogenesis by NNMT
por: Nguyen, Tin Tin Manh, et al.
Publicado: (2023)

Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity
por: van Haren, Matthijs J., et al.
Publicado: (2021)

Hypoxia induced LBH overexpression accelerates malignant progression in glioma
por: Zhang, Ke-Nan, et al.
Publicado: (2019)

Cancer-associated mesenchymal stem cells aggravate tumor progression
por: Kudo-Saito, Chie
Publicado: (2015)

P4HB and PDIA3 are associated with tumor progression and therapeutic outcome of diffuse gliomas
por: Zou, Hecun, et al.
Publicado: (2018)

SIRT3 regulates bronchial epithelium apoptosis and aggravates airway inflammation in asthma
por: Song, Jie, et al.
Publicado: (2022)

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression
por: Morelli, Maria Beatrice, et al.
Publicado: (2016)

Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells
por: Li, Guoli, et al.
Publicado: (2021)

Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
por: Zou, Wenyan, et al.
Publicado: (2019)

TGIF1 overexpression promotes glioma progression and worsens patient prognosis
por: Wang, Baoya, et al.
Publicado: (2022)

Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation
por: Jia, Pifeng, et al.
Publicado: (2017)

SERPINF1 Mediates Tumor Progression and Stemness in Glioma
por: Song, Lairong, et al.
Publicado: (2023)

Glioma-neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review)
por: Hua, Tianzhen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_p12arj2md1tg0sqdn1eusc6u4m