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Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome
Background: Previous studies have found that coronary artery calcification is closely associated with the occurrence of major adverse cardiac events (MACE). This study aimed to investigate the characteristics and clinical outcomes of different calcified plaques in patients with acute coronary syndro...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316434/ https://www.ncbi.nlm.nih.gov/pubmed/35887782 http://dx.doi.org/10.3390/jcm11144018 |
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author | Lei, Fangmeng Yin, Yanwei Liu, Xiaohui Fang, Chao Jiang, Senqing Xu, Xueming Sun, Sibo Pei, Xueying Jia, Ruyi Tang, Caiying Peng, Cong Li, Song Li, Lulu Wang, Yini Yu, Huai Dai, Jiannan Yu, Bo |
author_facet | Lei, Fangmeng Yin, Yanwei Liu, Xiaohui Fang, Chao Jiang, Senqing Xu, Xueming Sun, Sibo Pei, Xueying Jia, Ruyi Tang, Caiying Peng, Cong Li, Song Li, Lulu Wang, Yini Yu, Huai Dai, Jiannan Yu, Bo |
author_sort | Lei, Fangmeng |
collection | PubMed |
description | Background: Previous studies have found that coronary artery calcification is closely associated with the occurrence of major adverse cardiac events (MACE). This study aimed to investigate the characteristics and clinical outcomes of different calcified plaques in patients with acute coronary syndrome (ACS) by using optical coherence tomography (OCT). Methods: 258 ACS patients with calcified culprit plaques who underwent OCT-guided stent implantation were enrolled. They were divided into three subtypes based on the calcified plaque morphology, including eruptive calcified nodules, calcified protrusion, and superficial calcific sheet. Results: Compared with superficial calcific sheet and calcified protrusion, eruptive calcified nodules had the greatest calcium burden and a higher rate of stent edge dissection (p < 0.001) and incomplete stent apposition (p < 0.001). In a median follow-up period of 2 years, 39 (15.1%) patients experienced MACE (a composite event of cardiac death, target-vessel myocardial infarction, ischemia-driven revascularization), with a significantly higher incidence in the eruptive calcified nodules group (32.1% vs. 10.1% vs. 13.0%, p = 0.001). A multivariate Cox analysis demonstrated that the eruptive calcified nodules (hazard ratio 3.14; 95% confidence interval, 1.64–6.02; p = 0.001) were an independent predictor of MACE. Conclusions: MACE occurred more frequently in ACS patients with eruptive calcified nodules, and the eruptive calcified nodules were an independent predictor of MACE. |
format | Online Article Text |
id | pubmed-9316434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93164342022-07-27 Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome Lei, Fangmeng Yin, Yanwei Liu, Xiaohui Fang, Chao Jiang, Senqing Xu, Xueming Sun, Sibo Pei, Xueying Jia, Ruyi Tang, Caiying Peng, Cong Li, Song Li, Lulu Wang, Yini Yu, Huai Dai, Jiannan Yu, Bo J Clin Med Article Background: Previous studies have found that coronary artery calcification is closely associated with the occurrence of major adverse cardiac events (MACE). This study aimed to investigate the characteristics and clinical outcomes of different calcified plaques in patients with acute coronary syndrome (ACS) by using optical coherence tomography (OCT). Methods: 258 ACS patients with calcified culprit plaques who underwent OCT-guided stent implantation were enrolled. They were divided into three subtypes based on the calcified plaque morphology, including eruptive calcified nodules, calcified protrusion, and superficial calcific sheet. Results: Compared with superficial calcific sheet and calcified protrusion, eruptive calcified nodules had the greatest calcium burden and a higher rate of stent edge dissection (p < 0.001) and incomplete stent apposition (p < 0.001). In a median follow-up period of 2 years, 39 (15.1%) patients experienced MACE (a composite event of cardiac death, target-vessel myocardial infarction, ischemia-driven revascularization), with a significantly higher incidence in the eruptive calcified nodules group (32.1% vs. 10.1% vs. 13.0%, p = 0.001). A multivariate Cox analysis demonstrated that the eruptive calcified nodules (hazard ratio 3.14; 95% confidence interval, 1.64–6.02; p = 0.001) were an independent predictor of MACE. Conclusions: MACE occurred more frequently in ACS patients with eruptive calcified nodules, and the eruptive calcified nodules were an independent predictor of MACE. MDPI 2022-07-11 /pmc/articles/PMC9316434/ /pubmed/35887782 http://dx.doi.org/10.3390/jcm11144018 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lei, Fangmeng Yin, Yanwei Liu, Xiaohui Fang, Chao Jiang, Senqing Xu, Xueming Sun, Sibo Pei, Xueying Jia, Ruyi Tang, Caiying Peng, Cong Li, Song Li, Lulu Wang, Yini Yu, Huai Dai, Jiannan Yu, Bo Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome |
title | Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome |
title_full | Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome |
title_fullStr | Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome |
title_full_unstemmed | Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome |
title_short | Clinical Outcomes of Different Calcified Culprit Plaques in Patients with Acute Coronary Syndrome |
title_sort | clinical outcomes of different calcified culprit plaques in patients with acute coronary syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316434/ https://www.ncbi.nlm.nih.gov/pubmed/35887782 http://dx.doi.org/10.3390/jcm11144018 |
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