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Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study

(1) Background: Thrombophilia testing utility has remained controversial since its clinical introduction, because data on its influence on treatment decisions are limited. (2) Methods: We conducted a single-center retrospective cohort study of 3550 unselected patients referred for thrombophilia cons...

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Autores principales: Vrotniakaite-Bajerciene, Kristina, Tritschler, Tobias, Jalowiec, Katarzyna Aleksandra, Broughton, Helen, Brodard, Justine, Porret, Naomi Azur, Haynes, Alan, Rovo, Alicia, Kremer Hovinga, Johanna Anna, Aujesky, Drahomir, Angelillo-Scherrer, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316471/
https://www.ncbi.nlm.nih.gov/pubmed/35887951
http://dx.doi.org/10.3390/jcm11144188
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author Vrotniakaite-Bajerciene, Kristina
Tritschler, Tobias
Jalowiec, Katarzyna Aleksandra
Broughton, Helen
Brodard, Justine
Porret, Naomi Azur
Haynes, Alan
Rovo, Alicia
Kremer Hovinga, Johanna Anna
Aujesky, Drahomir
Angelillo-Scherrer, Anne
author_facet Vrotniakaite-Bajerciene, Kristina
Tritschler, Tobias
Jalowiec, Katarzyna Aleksandra
Broughton, Helen
Brodard, Justine
Porret, Naomi Azur
Haynes, Alan
Rovo, Alicia
Kremer Hovinga, Johanna Anna
Aujesky, Drahomir
Angelillo-Scherrer, Anne
author_sort Vrotniakaite-Bajerciene, Kristina
collection PubMed
description (1) Background: Thrombophilia testing utility has remained controversial since its clinical introduction, because data on its influence on treatment decisions are limited. (2) Methods: We conducted a single-center retrospective cohort study of 3550 unselected patients referred for thrombophilia consultation at the Bern University Hospital in Switzerland from January 2010 to October 2020. We studied the influence of thrombophilia testing results on treatment decisions and evaluated the association between thrombophilia and thromboembolic and pregnancy-related morbidity events after testing up to 03/2021. (3) Results: In 1192/3550 patients (34%), at least one case of thrombophilia was found and 366 (10%) had high-risk thrombophilia. A total of 211/3550 (6%) work-ups (111/826 (13%) with low-risk thrombophilia and 100/366 (27%) with high-risk thrombophilia) led to an appropriate decision to extend or initiate anticoagulation, and 189 (5%) negative results led to the withholding of anticoagulation therapy inappropriately. A total of 2492 patients (69%) were followed up for >30 days, with a median follow-up of 49 months (range, 1–183 months). Patients with high-risk thrombophilia had a higher risk of subsequent venous thromboembolic events and pregnancy-related morbidity compared to those without thrombophilia. (4) Conclusions: Our study demonstrated the limited usefulness of thrombophilia work-up in clinical decision-making. High-risk thrombophilia was associated with subsequent venous thromboembolism and pregnancy-related morbidity.
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spelling pubmed-93164712022-07-27 Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study Vrotniakaite-Bajerciene, Kristina Tritschler, Tobias Jalowiec, Katarzyna Aleksandra Broughton, Helen Brodard, Justine Porret, Naomi Azur Haynes, Alan Rovo, Alicia Kremer Hovinga, Johanna Anna Aujesky, Drahomir Angelillo-Scherrer, Anne J Clin Med Article (1) Background: Thrombophilia testing utility has remained controversial since its clinical introduction, because data on its influence on treatment decisions are limited. (2) Methods: We conducted a single-center retrospective cohort study of 3550 unselected patients referred for thrombophilia consultation at the Bern University Hospital in Switzerland from January 2010 to October 2020. We studied the influence of thrombophilia testing results on treatment decisions and evaluated the association between thrombophilia and thromboembolic and pregnancy-related morbidity events after testing up to 03/2021. (3) Results: In 1192/3550 patients (34%), at least one case of thrombophilia was found and 366 (10%) had high-risk thrombophilia. A total of 211/3550 (6%) work-ups (111/826 (13%) with low-risk thrombophilia and 100/366 (27%) with high-risk thrombophilia) led to an appropriate decision to extend or initiate anticoagulation, and 189 (5%) negative results led to the withholding of anticoagulation therapy inappropriately. A total of 2492 patients (69%) were followed up for >30 days, with a median follow-up of 49 months (range, 1–183 months). Patients with high-risk thrombophilia had a higher risk of subsequent venous thromboembolic events and pregnancy-related morbidity compared to those without thrombophilia. (4) Conclusions: Our study demonstrated the limited usefulness of thrombophilia work-up in clinical decision-making. High-risk thrombophilia was associated with subsequent venous thromboembolism and pregnancy-related morbidity. MDPI 2022-07-19 /pmc/articles/PMC9316471/ /pubmed/35887951 http://dx.doi.org/10.3390/jcm11144188 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vrotniakaite-Bajerciene, Kristina
Tritschler, Tobias
Jalowiec, Katarzyna Aleksandra
Broughton, Helen
Brodard, Justine
Porret, Naomi Azur
Haynes, Alan
Rovo, Alicia
Kremer Hovinga, Johanna Anna
Aujesky, Drahomir
Angelillo-Scherrer, Anne
Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study
title Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study
title_full Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study
title_fullStr Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study
title_full_unstemmed Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study
title_short Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study
title_sort thrombophilia impact on treatment decisions, subsequent venous or arterial thrombosis and pregnancy-related morbidity: a retrospective single-center cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316471/
https://www.ncbi.nlm.nih.gov/pubmed/35887951
http://dx.doi.org/10.3390/jcm11144188
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